Results 91 to 100 of about 384,997 (202)

Why Circulating Interleukin‐6 Is Not Yet a Standalone Clinically Actionable Biomarker in HFrEF: A Context‐of‐Use Review

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
Clinical and translational readiness of IL‐6 measurement in HFrEF. ABSTRACT Background Interleukin‐6 (IL‐6) is frequently measured in heart failure with reduced ejection fraction (HFrEF), but its clinical utility remains unclear. Objectives To assess IL‐6 as a biomarker in HFrEF, with emphasis on the effect of treatments (pharmacodynamics) and ...
Yongxin Ye, Martina Colombo, Jennifer Meessen, Benoit Tyl, Deborah Novelli, Negin Hajizadeh, Hans‐Peter Brunner‐La Rocca, Adriaan Voors, Sara Klas, Stephan Schwers, Bjarke Follin, Roberto Latini   +11 more
wiley   +1 more source

Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Arthritis Research & Therapy, 2016
Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney 1 Erratum Unfortunately, after publication of this article [1], it was noticed that the name of Jeffrey N ...
J. Miner, P. Tan, D. Hyndman, Sha Liu, C. Iverson, Payal Nanavati, D. Hagerty, Kimberly Manhard, Zan-Cong Shen, J. Girardet, L. Yeh, R. Terkeltaub, B. Quart   +12 more
semanticscholar   +1 more source

Schematic representations illustrating how urate may activate Nrf2 and thus protects against oxidative stresses.

, 2014
Urate may be accumulated into cells via undefined transporters. It led to Nrf2 accumulation by inhibiting its ubiquitination and degradation and promoted Nrf2 translocate into nuclei, where Nrf2 may transactivate the transcription of antioxidant enzyme ...
Ning Zhang (23771), Li-Fang Hu (286319), Guan-Qun Zhang (464577), Chun-Feng Liu (329344), Tingting Huang (496866), Xiao-Yan Peng (587956), Qi-Lin Zhang (587955), Da Li (194457), Wei-Feng Luo (587957), Hai-Yang Shu (587954)   +9 more
core   +1 more source

Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways [PDF]

, 2015
URAT1 (slc22a12) was identified as the transporter responsible for renal reabsorption of the medically important compound, uric acid. However, subsequent studies have indicated that other transporters make contributions to this process, and that URAT1 ...
Nigam, Sanjay K, Jamshidi, Neema, Eraly, Satish A, Liu, Henry C   +3 more
core   +1 more source

Ultrafast python‐integrated single‐entity electrochemical sensor for detecting glycated albumin

The FEBS Journal, Volume 293, Issue 19, Page 5898-5907, October 2026.
Traditional biosensors suffer from the fact that recognition receptors are immobilised and that they denature on electrodes. Instead here we use receptors freely in solution, minimising surface compression and preserving activity to boost signal efficiency. Python‐driven processing turns the electrochemical response into a rapid, robust readout.
Zihni Onur Uygun
wiley   +1 more source

Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling

Clinical Kidney Journal, 2016
Background In the setting of chronic kidney disease (CKD), altered extra-renal urate handling may be necessary to regulate plasma uric acid. The Remote Sensing and Signaling Hypothesis (Nigam S. What do drug transporters really do?
V. Bhatnagar, E. Richard, Wei Wu, C. Nievergelt, M. Lipkowitz, Janina M. Jeff, A. Maihofer, S. Nigam   +7 more
semanticscholar   +1 more source

Proposed model for the action of UA-lowering drugs on intestinal UA transporters.

, 2019
Based on the results of this study, as well as previous reports, we suggest the expressed transporters Oat1, Oat3, Mrp4, and ABCG2 to be related to urate transport in the intestine. ABCG2 was inhibited by UA-lowering drugs used in this study.
Kyoko Fujita (257442), Masahiro Iijima (5831621), Hiroki Yamada (5435), Kimiyoshi Ichida (3095874)   +3 more
core   +1 more source

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

, 2021
Elevated serum urate levels cause gout and correlate with cardio-metabolic diseases via poorly understood mechanisms. We performed a trans-ethnic genome-wide association study of serum urate among 457,690 individuals, identifying 183 loci (147 novel ...
Thiery, Joachim, Carroll, Robert J., Hwang, Shih-Jen, Zonderman, Alan B., Ryan, Kathleen A., Psaty, Bruce M., Kirsten, Holger, Nutile, Teresa, Rabelink, Ton J., Pirastu, Mario, Amin, Najaf, Kerr, Shona M., Jakobsdottir, Johanna, Mohlke, Karen L., Felicita, Sala Cinzia, Heid, Iris M., Milaneschi, Yuri, Lewis, Raychel M., Nalls, Mike A., Peters, Annette, de Vries, Aiko P. J., Hofer, Edith, Robino, Antonietta, Rettig, Rainer, Okada, Yukinori, Concas, Maria Pina, Gordon, Scott D., Gaziano, John, Ho, Kevin, Boutin, Thibaud S., Martin, Nicholas G., Parsa, Afshin, Ruggiero, Daniela, Mononen, Nina, Cocca, Massimiliano, Campbell, Harry, Bakker, Stephan J. L., Tönjes, Anke, Bochud, Murielle, Boerwinkle, Eric, Afaq, Saima, Joshi, Peter K., Butterworth, Adam S., Ärnlöv, Johan, Evans, Michele K., Kronenberg, Florian, Catamo, Eulalia, Campana, Eric, Schmidt, Reinhold, Gögele, Martin, Meisinger, Christa, De Grandi, Alessandro, Gansevoort, Ron T., Loeffler, Markus, Böger, Carsten A., Demirkan, Ayşe, Perls, Thomas, Li, Yong, Krämer, Bernhard K., Whitfield, John B., Noordam, Raymond, Wilson, Otis D., Poulain, Tanja, März, Winfried, Gorski, Mathias, Völker, Uwe, Cifkova, Renata, de Mutsert, Renée, Lyytikäinen, Leo-Pekka, Nadkarni, Girish N., Brumat, Marco, Ingelsson, Erik, Campbell, Archie, Jonsdottir, Ingileif, Teren, Andrej, Penninx, Brenda W. J. H., Lehtimäki, Terho, Kleber, Marcus E., Huang, Wei, Rueedi, Rico, Tajuddin, Salman M., Ehret, Georg, Mook-Kanamori, Dennis O., Ciullo, Marina, Nauck, Matthias, Padmanabhan, Sandosh, Hoppmann, Anselm, Delgado, Graciela, Coresh, Josef, Thorsteinsdottir, Unnur, Halperin Kuhns, Victoria L., Raitakari, Olli T., Vitart, Veronique, Devuyst, Olivier, Hamet, Pavel, Eckardt, Kai-Uwe, Körner, Antje, Rice, Kenneth M., Ghasemi, Sahar, van der Most, Peter J., Sulem, Patrick, Porteous, David J., Bergmann, Sven, Haller, Toomas, Teumer, Alexander, Woodward, Owen M., Harris, Tamara B., Pattaro, Cristian, Baptista, Daniela, Mishra, Pashupati P., Giedraitis, Vilmantas, Tremblay, Johanne, Strauch, Konstantin, Thio, Chris H. L., Prins, Bram, Pistis, Giorgio, O’Connell, Jeffrey R., Magi, Reedik, Yu, Zhi, Cusi, Daniele, Toniolo, Daniela, Jonsson, Helgi, Nikus, Kjell, Gudnason, Vilmundur, Vaccargiu, Simona, Yang, Qiong, Pendergrass, Sarah A., Kubo, Michiaki, Jung, Bettina, Nolte, Ilja M., Loos, Ruth J. F., Rudan, Igor, Waldenberger, Melanie, Stefansson, Kari, Gasparini, Paolo, Ikram, M. Arfan, Matsuda, Koichi, Kovacs, Peter, Hicks, Andrew A., Vollenweider, Peter, Girotto, Giorgia, Burkhardt, Ralph, Sedaghat, Sanaz, Lehne, Benjamin, Giri, Ayush, Hayward, Caroline, van der Harst, Pim, Schmidt, Helena, Kähönen, Mika, Sveinbjornsson, Gardar, Ning, Boting, Raffield, Laura M., Gieger, Christian, Holm, Hilma, Köttgen, Anna, Fuchsberger, Christian, Kiess, Wieland, Qiu, Chengxiang, Kühnel, Brigitte, Josyula, Navya Shilpa, Smith, Blair H., Koenig, Wolfgang, Lange, Leslie A., Müller-Nurasyid, Martina, La Bianca, Martina, Tin, Adrienne, Uitterlinden, André G., Kooner, Jaspal S., O'Donnell, Christopher, Smith, Albert V., Bansal, Nisha, Chambers, John C., Polasek, Ozren, Saba, Yasaman, Waeber, Gerard, Biino, Ginevra, Shaffer, Christian M., Akiyama, Masato, Corre, Tanguy, Kamatani, Yoichiro, van Duijn, Cornelia M., Montgomery, Grant W., Spracklen, Cassandra N., Susztak, Katalin, Olafsson, Isleifur, Marten, Jonathan, Endlich, Karlhans, Liu, Jun, Rheinberger, Myriam, Xu, Yizhe, Krajcoviechova, Alena, Snieder, Harold, Sieber, Karsten B., Wuttke, Matthias, Zhang, Weihua, Bottinger, Erwin P., Stumvoll, Michael, Hutri-Kähönen, Nina, Wilson, James F., Chu, Audrey Y., Wilson, James G., Wild, Sarah H., Li, Man, Meitinger, Thomas, Pirastu, Nicola, Noce, Damia, de Borst, Martin H., Salvi, Erika, Gudbjartsson, Daniel F., Verweij, Niek, Hung, Adriana M., Mascalzoni, Deborah, Scholz, Markus, Ponte, Belen, Horn, Katrin, Kanai, Masahiro, Preuss, Michael H., O'Connor, Luke, Biggs, Mary L., Dittrich, Katalin, Pramstaller, Peter P., Mahajan, Anubha, Edwards, Todd L., Rizzi, Federica, Metspalu, Andres   +224 more
core   +1 more source

Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: insight into pathogenesis of hypouricemia in SIADH

Clinical and Experimental Nephrology, 2016
BackgroundHypouricemia is pathognomonic in syndrome of inappropriate secretion of antidiuretic hormone (SIADH) but the underlying mechanism remains unclear.
Kei Taniguchi, Yoshifuru Tamura, T. Kumagai, S. Shibata, S. Uchida   +4 more
semanticscholar   +1 more source

Dataset for: Urate transport function of rat sodium-dependent nucleobase transporter 1

, 2018
Sodium-dependent nucleobase transporter 1 (SNBT1) is a nucleobase-specific transporter identified in our recent study. In an attempt to search for its potential substrates other than nucleobases in the present study, we could successfully find urate, a ...
Hiroaki Yuasa (5163320), Chihiro Murata (5163332), Tomoya Yasujima (5163317), Kinya Ohta (5163323), Katsuhisa Inoue (5163326), Yoshihisa Mimura (5163338), Tomoaki Murata (5163335), Masahiko Ohkubo (5163329)   +7 more
core   +1 more source