Results 71 to 80 of about 384,997 (202)

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia

Pharmacological Research
Background: Although the intestine substantially contributes to daily urate clearance, intestinal urate-lowering strategies remain limited, particularly interventions that coordinately regulate transport, barrier integrity, inflammation, and microbial ...
Mingyuan Fan, Jiushu Yuan, Hongyan Xie, Qian Li, Dingyi Lu, Sai Zhang, Qiangyan Wang, Gang Wang, Chunguang Xie, Hong Gao   +9 more
doaj   +1 more source

Uric acid transporter inhibitors for gout

ADMET and DMPK, 2017
Gout is a common inflammatory arthritis that is caused by chronically-elevated serum uric acid (sUA) levels (hyperuricemia). In humans, sUA levels are predominantly controlled by a variety of transporters that mediate the elimination of uric acid through
Philip K. Tan, Jeffrey N. Miner
doaj   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Longan Seed Extract Reduces Hyperuricemia via Modulating Urate Transporters and Suppressing Xanthine Oxidase Activity

, 2014
[[abstract]]Hyperuricemia causes gouty arthritis, kidney disease, heart disease, and other diseases. Xanthine oxidase (XOD) and urate transporters play important roles in urate homeostasis. Numerous plants have been identified as XOD inhibitors.
Chien-Wei Hou;Ying-Chung Lee;Hsiao-Fang Hung;Hua-Wen Fu;Kee-Ching Jeng
core   +1 more source

Update on hyperuricaemia and gout with evidence based management guidelines

South African Family Practice, 2015
Gout is now the leading cause of inflammatory arthritis, affecting 1–2% of the population. The metabolic syndrome, cardiovascular risk factors, cardiovascular events and mortality are more common with gout.
Girish M. Mody
doaj   +1 more source

Reprogramming Native Cryptic Plasmids Enables Antibiotic‐Selection‐Free Urate Degradation by Escherichia coli Nissle 1917

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Reprogramming native cryptic plasmids of Escherichia coli Nissle 1917 enabled antibiotic‐selection‐free and oxygen‐adaptive urate degradation. The engineered strain reduced uric acid levels and alleviated hyperuricemia‐associated renal and inflammatory abnormalities in mice, supporting endogenous plasmid engineering as a strategy for live ...
Yuan Chi, Shiying Wu, Fei Lin, Tingwen Fan, Hongwei Liu, Huaiyi Yang   +5 more
wiley   +1 more source

Konjac glucomannan improves hyperuricemia through regulating xanthine oxidase, adenosine deaminase and urate transporters in rats

Journal of Functional Foods, 2018
To develop a more effective and safer treatment for Hyperuricemia (HUA), this research investigated the anti-hyperuricemic mechanism of KGM from the perspectives of uric acid (UA) production and excretion in rat model.
Yuan Zhang, Liling Deng, Chunmei Wu, Lian-Ji Zheng, Geng Zhong   +4 more
semanticscholar   +1 more source