Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium. [PDF]
Int J Mol Sci, 2020 The choroid plexus plays a central role in the regulation of the microenvironment of the central nervous system by secreting the majority of the cerebrospinal fluid and controlling its composition, despite that it only represents approximately 1% of the ...
Chiba Y +8 more
europepmc +3 more sources
Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort. [PDF]
Cells, 2022 The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body.
Vávra J +5 more
europepmc +3 more sources
SLC2A9 is a high-capacity urate transporter in humans. [PDF]
PLoS Medicine, 2008 BackgroundSerum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease.
Mark J Caulfield +36 more
doaj +2 more sources
Regulation of Urate Homeostasis by Membrane Transporters
Gout, Urate, and Crystal Deposition DiseaseUric acid is the final purine metabolite in humans. Serum urate levels are regulated by a balance between urate production, mainly in the liver, and its excretion via the kidneys and small intestine.
Tappei Takada +5 more
semanticscholar +2 more sources
Food & Medicine HomologyHyperuricemia (HUA) has gradually become the fourth most prevalent chronic disease and the incidence rate is getting younger. In this study, Lophatherum gracile Brongn.
Yu Lu +5 more
doaj +2 more sources
Urate Transporters in the Kidney: What Clinicians Need to Know. [PDF]
Electrolyte Blood Press, 2021 Urate is produced in the liver by the degradation of purines from the diet and nucleotide turnover and excreted by the kidney and gut. The kidney is the major route of urate removal and has a pivotal role in the regulation of urate homeostasis ...
Chung S, Kim GH.
europepmc +2 more sources
Extract of Aster glehni ameliorates potassium oxonate-induced hyperuricemia by modulating renal urate transporters and renal inflammation by suppressing TLR4/MyD88 signaling. [PDF]
Food Sci Biotechnol, 2022 Jeong J +5 more
europepmc +2 more sources
Role of urate transporters in the kidneys and intestine in uric acid homeostasis. [PDF]
Kidney Res Clin PractHyperuricemia is frequently observed in patients with chronic kidney disease and is recognized as a significant contributor to the progression of renal dysfunction. On the other hand, hypouricemia, although less thoroughly studied, has been implicated in
Kim SH, Shin J, Son HE, Kang DH.
europepmc +2 more sources
Genetic polymorphisms and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia. [PDF]
Clin Exp Med, 2023 Gout is a common crystal induced disease of high personal and social burden, characterised by severe arthritis and comorbidity if untreated. Impaired function of ABCG2 transporter is causative in gout and may be responsible for renal-overload type ...
Pálinkás M +11 more
europepmc +2 more sources
Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation. [PDF]
iScienceSummary Hyperuricemia (HUA), caused by purine disorders, can lead to gouty arthritis (GA). Kaempferol (KPF), a natural flavonoid, has anti-inflammatory properties, though its mechanism in treating HUA combined with GA remains unclear.
Huang Y +9 more
europepmc +2 more sources