Results 41 to 50 of about 3,983 (152)

PLACENTAL URIC ACID TRANSPORTER GLUT9 IS MODULATED BY FREE IODINE [PDF]

open access: yes, 2014
PLACENTAL URIC ACID TRANSPORTER GLUT9 IS MODULATED BY FREE IODINE Objectives: Materno-fetal transplacental transport is crucial for the fetal well-being.
Fine, Michael   +7 more
core  

The haplotype association among all 21 SNPs in the GLUT9 gene.

open access: yes, 2012
The haplotype association among all 21 SNPs in the GLUT9 gene.
Dongmei Meng (180462)   +12 more
core   +1 more source

Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats

open access: yesJournal of Ginseng Research, 2021
Background: Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders.
Yoon-Young Sung   +2 more
doaj   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

open access: yesRheumatology &Autoimmunity, Volume 6, Issue 3, Page 169-176, September 2026.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li   +5 more
wiley   +1 more source

Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8230-8241, September 2026.
ABSTRACT Aim Sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real‐world data and Mendelian randomisation (MR) analysis. Materials and Methods We
Hong Sang Choi   +7 more
wiley   +1 more source

Chicory (Cichorium intybus L.) inhibits renal reabsorption by regulating expression of urate transporters in fructose-induced hyperuricemia

open access: yesJournal of Traditional Chinese Medical Sciences, 2019
Objective: Hyperuricemia is an excess of urate in blood. The kidneys play important parts in urate excretion, which involves handling reabsorption and secretion.
Yu Wang   +4 more
doaj   +1 more source

Association Between the Planetary Health Diet Index and Serum Uric Acid Levels and Incident Hyperuricemia: Findings From an Iranian Prospective Cohort Study

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
In 5773 adults followed for ~5 years, higher EAT–Lancet diet adherence was consistently associated with lower incident hyperuricemia and lower serum uric acid. Associations were observed across three EAT–Lancet scoring approaches and persisted after adjustment for established dietary‐quality indices. Baseline HOMA‐IR may partly mediate this association,
Farzam Kamrani   +7 more
wiley   +1 more source

Association Between TyG‐WC and Gout in American Adults: A Cross‐Sectional Study of NHANES 2003–2018

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The triglyceride‐glucose (TyG) index is widely used as a surrogate marker of insulin resistance. Indices that combine TyG with anthropometric measures may better reflect metabolic dysfunction and central adiposity. However, evidence regarding the association between TyG‐waist circumference (TyG‐WC) and gout among U.S ...
Shenlong Yi   +7 more
wiley   +1 more source

The in-silico evaluation of important GLUT9 residue for uric acid transport based on renal hypouricemia type 2

open access: yes, 2023
Uric acid is the end product of purine metabolism. Uric acid transporters in the renal proximal tubule plays a key role in uric acid transport. Functional abnormalities in these transporters could lead to high or low levels of uric acid in the blood ...
Shahsavari, S   +5 more
core   +1 more source

Glucose Transporter 1 in Health and Disease

open access: yesMedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai   +3 more
wiley   +1 more source

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