Results 51 to 60 of about 3,983 (152)

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Alterations of Renal Epithelial Glucose and Uric Acid Transporters in Fructose Induced Metabolic Syndrome

Kidney & Blood Pressure Research, 2018
Background/Aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric
Hwee-Yeong Ng, Yueh-Ting Lee, Wei-Hung Kuo, Pei-Chen Huang, Wei-Chia Lee, Chien-Te Lee   +5 more
doaj   +1 more source

The associations in the distributions of genotypes and allele frequency for two polymorphisms (rs13124007 and rs6850166) in the GLUT9 gene in cases and controls.

, 2012
The associations in the distributions of genotypes and allele frequency for two polymorphisms (rs13124007 and rs6850166) in the GLUT9 gene in cases and controls.
Dongmei Meng (180462), Lin Han (113452), Xu Ma (45624), Jian Luan (180456), Nan Chu (180449), Binbin Wang (161690), Shiguo Liu (180495), Jing Wang (4865), Zhimin Miao (180489), Yunlong Wang (180471), Peisu Suo (180476), Changgui Li (180443), Longfei Cheng (180481)   +12 more
core   +1 more source

PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with hyperuricemia. How PFOS affects urate-related responses in human proximal-tubule cells remains incompletely understood.
Haotian Cui, Chen Li, Wei Zhang, Weipeng Yang, Ruihan Ge, Xinmin Wang, Le Zhang   +6 more
doaj   +1 more source

Homozygous mutations of GLUT9 cause severe renal hypouricemia

, 2009
Hereditary hypouricemia may result from mutations in the renal tubular uric acid transporter URAT1. Whether mutation of other uric acid transporters produces a similar phenotype is unknown.
Sawyer, Lindsay, Amariglio, Ninette, Campbell, Susan, Shu, Xinhua, Richardson, William, Gray, Nicola K., Rechavi, Gideon, Dinour, Dganit, S. Campbell, L. Sawyer, E. J. Holtzman, J. Weissgarten, A. F. Wright, N. K. Gray, G. Rechavi, M. R. Millar, X. Shu, N. Amariglio, D. Dinour, M. Goldman, B.-A. Sela, L. Ganon, H. Bahat, W. Richardson   +23 more
core   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, Volume 78, Issue 6, Page 781-787, June 2026.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

Combined Anserine/Carnosine Exerts Anti‐Hyperuricemic, Nephroprotective, and Gut Microbiota‐Modulating Effects in Hyperuricemia Mice

Food Bioengineering, Volume 5, Issue 2, Page 194-208, June 2026.
Mixed carnosine and anserine significantly reduce serum uric acid, protect the kidneys, and modulate gut microbiota, demonstrating potent therapeutic potential against hyperuricemia. ABSTRACT The anti‐hyperuricemic, nephroprotective, and gut microbiota modulation effects of mixed carnosine and anserine (MAC) with the fixed ratio of 10:1 were evaluated ...
Jingjing Huang, Zheng Dang, Yuzhi Zhang, Haisheng Lin, Lei Du, Jie Zhang, Li Zhao, William T. H. Chang, Xiang‐Ru Kong, Wei‐Ting Tseng, Jingli Xie   +10 more
wiley   +1 more source

Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate

Marine Drugs, 2019
The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high ...
Yung-Tsung Chau, Hsin-Yuan Chen, Po-Han Lin, Shih-Min Hsia   +3 more
doaj   +1 more source

Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC–MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
UPLC‐MS/MS analysis of hawthorn flavonoids combined with network pharmacology, molecular docking, and molecular dynamics studies predicted vitexin as a key compound acting on the PPARγ/ABCG2 pathway. In a hyperuricemic mouse model, vitexin effectively lowered serum uric acid by enhancing renal and intestinal urate excretion, inhibiting urate production,
Shu‐Yu Wu, Kai‐Wen Kang, Dan‐Yu Huang, Shu‐Ying Li, Hao Zheng, Ri‐Hui Wu, Hui‐Qing Lv, Wan‐Bin Song, Jing Chen, Cheng‐Ping Wen, Li‐She Gan, Xiao Yuan   +11 more
wiley   +1 more source