Results 71 to 80 of about 3,983 (152)

Efek Pemberian Ekstrak Etanol Kulit Melinjo (Gnetum gnemon) terhadap Ekspresi Gen URAT1 dan GLUT9 pada Tikus Wistar Model Hiperurisemia

, 2023
Hyperuricemia can occur because uric acid levels in the blood exceed normal limits. Where uric acid itself is the end product of purine metabolism in the body. Prolonged hyperuricemia will lead to gout, the consequences of the disease will be detrimental
Sofyan, Nurul Amalia
core   +1 more source

Identification of basolateral localization motifs of the urate transporter GLUT9 using functional studies. [PDF]

, 2023
The GLUT9 transporter, coded by the SLC2A9 gene, is one of the key proteins enabling the trasnfer of uric acid across the membrane in epithelial cells of the proximal tubule.
Pácalová, Eliška
core  

Effect of Skin Melinjo Extract (Gnetum Gnemon) On Expression URAT1 and GLUT9 Genes In Hyperuricemia [PDF]

, 2023
Hyperuricemia is defined as a metabolic syndrome disease with markers characteristic of uric acid production that exceed normal limits. Normal uric acid levels range from 3.4-7.0 mg/dl in adult men and 2.4 -6.0 mg/dl in adult women.
Yetty Machrina, Nurul Amalia Sofyan, Syafruddin Ilyas   +2 more
core  

Immunocytochemical analysis of Xenopus oocytes.

, 2014
Immunocytochemical analysis of Xenopus oocytes injected with 50 ng of cRNA encoding the wild-type (wt) or mutant GLUT9 performed with rabbit anti-SLC2A9 polyclonal antibody.
Marketa Pavlikova (5660785), Andrea Mancikova (636858), Blanka Stibůrková (564063), Vladimir Krylov (636859), Olha Hurba (636857), Karel Pavelka (605302)   +5 more
core   +1 more source

SLC2A9 is a high-capacity urate transporter in humans [PDF]

, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M, Kumari, Meena, Charchar, Fadi J, Samani, NJ, Elliott Paul, Kooner J, M. Marmot (7611368), Eyheramendy S, Dobson Richard J, Marmot, Michael, Connell, JM, Philip Howard, Caulfield, Mark J., J. Chambers (3846385), Connell John M, Munroe, Patricia B, John Chambers, Marmot Michael, Dobson, RJ, Charchar Fadi J, Doblado, M, Kumari, M, Morris Brown, Dobson RJ, Elliott, Paul, Gudrun Veldre, R. J. Dobson (7602557), Caulfield MJ, Iacone, Roberto, Laan, Maris, Lathrop, G. Mark, A. Dominiczak (7611551), Kooner, Jaspal, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Samani, Nilesh J., Francesco P Cappuccio, Lann, Maris, P. Howard (7611350), Nilesh J. Samani (7579793), Farrall, M, K. H. Moley (7611569), Newhouse, Stephen J, Munroe PB, Veldre, Gudrun, Wallace Chris, Evans, S, Chambers, John, Howard P, Martin Farrall, Deb O'Neill, Witkowska K, Newhouse, SJ, M. Laan (7602659), Maris Laan, Charchar FJ, Munroe Patricia B, M. Viigimaa (7602620), Cheeseman C., Dominiczak A, M. Doblado (7611566), Evans Sarah, Onipinla A, Shaw-Hawkins Sue, Lathrop GM, Evans, Sarah, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Witkowska, K, Wallace, C, M. Farrall (6522599), Moley, KH, Charchar, Fadi J., Brunner E, Eric Brunner, Chris Wallace, Brunner Eric, G. M. Lathrop (7611353), O'Neill, D, Dobson, Richard J., G Mark Lathrop, Richard J Dobson, F. J. Charchar (7591784), Howard Philip, Cappuccio FP, Cappuccio, Francesco, Evans S, E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Moley, Kelle Harbert, F. P. Cappuccio (7611356), Wallace, Chris, Connell, J. M. C., Cheeseman, Chris, Sue Shaw-Hawkins, Stephen J Newhouse, Dobson, Richard, Samani NJ, Kelle H Moley, Patricia B Munroe, Howard, P, Wallace C, Cappuccio Francesco P, Veldre Gudrun, Caulfield Mark J, Manuel Doblado, Moley Kelle H, Elin Org, Viigimaa, M, S. J. Newhouse (7602371), Onipinla, Abiodun, Michael Marmot, Elliot, Paul, Dominiczak, A, Veldre G, R. Iacone (7611362), Abiodun Onipinla, Mark J Caulfield, Sarah Evans, Marmot M, Cheeseman Chris, Kooner, J, Brown Morris, J. Kooner (7609340), Laan, M, Moley, Kelle H, Witkowska Kate, Moley, Kelle H., C. Ji (7611359), Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Pasquale Strazzullo, Laan M, D. O'Neill (7611560), Brown, M. J. (Morris Jonathan), Shaw-Hawkins, Sue, Chris Cheeseman, Samani, Nilesh J, Strazzullo, P, Dobson, Richard; id_orcid, Cappuccio, Francesco P., K. Witkowska (7611563), Munroe, Patricia B., Cappucio, Francesco P., Charchar, FJ, Brunner, Eric, Newhouse SJ, Witkowska, Kate, Kate Witkowska, O'Neill, Deb, Moley KH, Elliott, P, Org, E, Lathrop G. Mark, Paul Elliott, E. Org (7602644), O'Neill Deb, Doblado Manuel, Caulfield, Mark, Marmot, Michael G., John M Connell, Onipinla Abiodun, Caulfield, MJ, Org E, J. M. Connell (7602551), Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Susana Eyheramendy, Newhouse, Stephen J., Brown, Morris, Jaspal Kooner, S. Eyheramendy (7611197), Roberto Iacone, Samani Nilesh J, Fadi J Charchar, Shaw Hawkins S, Strazullo, Pasquale, Cheeseman, C, Elliott P, Strazzullo Pasquale, M. Brown (3020991), Ji Chen, Cheeseman, Chris (Christopher I.), Meena Kumari, Chambers, John, MD, Org, Elin, Anna Dominiczak, S. Evans (6370628), Dominiczak Anna, Iacone, R, Dobson, Richard J, Brunner, E, Margus Viigimaa, P. Elliott (1293702), Viigimaa, Margus, Chen Ji, Connell, John M., Farrall M, Eyheramendy, S, M. J. Caulfield (7602383), Connell, John M, O'Neill D, Eyheramendy, Susana, Chambers J, C. Cheeseman (7611572), Laan Maris, Newhouse Stephen J, Caulfield, Mark J, Ji, C, Doblado, Manuel, Shaw-Hawkins, S, Dominiczak, A. F., Ji C, G. Veldre (7602656), Lathrop, G Mark, Eyheramendy Susana, A. Onipinla (7602377), Cappuccio, Francesco P, M. Kumari (7602503), Kooner Jaspal, Dominiczak, Anna, Nilesh J Samani, Brown M, Chambers, J, Viigimaa M, Strazzullo, Pasquale, Connell JM, Howard, Philip, Ji, Chen, Kumari M, O'Neill, Deb   +241 more
core   +1 more source

Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats

Kidney & Blood Pressure Research, 2018
Background/Aims: The objective of this study is to evaluate the hypouricemic and nephroprotective effects of an active fraction from Polyrhachis vicina Roger (AFPR) in potassium oxonate-induced hyperuricemic rats.
Qibiao Su, Hua Su, Zhihuan Nong, Dongmei Li, Laiyou Wang, Shifeng Chu, Lizhen Liao, Jie Zhao, Xianbiao Zeng, Qikang Ya, Fei He, Wenjie Lu, Baowei Wei, Guining Wei, Naihong Chen   +14 more
doaj   +1 more source

Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats

Metabolites
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) fruit has medicinal and food applications and exhibits beneficial pharmacological properties. This study aimed to explore the hypouricemic effect of C.
Ruoling Xu, Peng Deng, Yiren Ma, Kui Li, Fucai Ren, Ning Li   +5 more
doaj   +1 more source

Urate uptake in oocytes.

, 2014
Transport activity is expressed as % urate uptake in oocytes injected with 50 ng of cRNA encoding the wild-type or the particular analyzed allelic variants. The uptake of 100 µM [14C]urate in oocytes was measured after 30 minutes incubation.
Marketa Pavlikova (5660785), Andrea Mancikova (636858), Blanka Stibůrková (564063), Vladimir Krylov (636859), Olha Hurba (636857), Karel Pavelka (605302)   +5 more
core   +1 more source

Exploration of leech therapy in treating gouty rats and its uric acid lowering mechanism

Journal of Ayurveda and Integrative Medicine
Background: Gout is a hyperuricemia (HUA)-related inflammatory reaction in the joints. Leech therapy has been effective in the gout, but the exact mechanism is unclear.
Gao Ling chao, Li Xiang shen, Pan Li, Peng Xiao hua, Mo Ling ling, Zhou Yuan yuan, Chen Chuang   +6 more
doaj   +1 more source

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats

Pharmaceutical Biology, 2019
Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie   +8 more
doaj   +1 more source