Results 61 to 70 of about 3,983 (152)

Clinical and Functional Characterization of a Novel URAT1 Dysfunctional Variant in a Pediatric Patient with Renal Hypouricemia

Applied Sciences, 2019
Renal hypouricemia (RHUC) is caused by an inherited defect in the main (reabsorptive) renal urate transporters, URAT1 and GLUT9. RHUC is characterized by decreased concentrations of serum uric acid and an increase in its excretion fraction.
Blanka Stiburkova, Jana Bohata, Iveta Minarikova, Andrea Mancikova, Jiri Vavra, Vladimír Krylov, Zdenek Doležel   +6 more
doaj   +1 more source

Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi, Basma Hanbali, Mai Elaarag, Zainab Fares, Enas A. Al‐Hurani, Sally R. Al‐Zoubi, Mohanad Shkoor, Abdelali Agouni   +7 more
wiley   +1 more source

Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9

, 2002
Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity.
Neama, G., Carter, SD, Mobasheri, A, Bell, S, Mobasheri, A., Bell, S., Neama, G, Carter, S. D., Richardson, S.; id_orcid, Richardson, S   +9 more
core   +2 more sources

A Possible Therapeutic Application of the Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease

Cells
The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama   +4 more
doaj   +1 more source

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source

Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1

Acta Materia Medica
Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport.
Mei Wang, Shujing Xu, Xiaoyu Shi, Edeildo Ferreira da Silva-Júnior, Peng Zhan   +4 more
doaj   +1 more source

Nonlinear Association of the Triglyceride–Glucose Index With Hyperuricemia Among Young Chinese Adults

The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
ABSTRACT The triglyceride–glucose (TyG) index is a practical surrogate of insulin resistance, but evidence on its association with hyperuricemia (HUA) in young adults is limited. We examined the nonlinear association between TyG and HUA in a young Chinese population. This cross‐sectional study included 6343 adults aged 18–45 years who underwent routine
Ri Liu, Huian Ge, Chen Qiu, Zetao Wu
wiley   +1 more source

Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota–Antioxidant Pathway Modulation

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Perennial ryegrass supplementation modulates UA‐metabolism in goslings by reducing serum uric acid and creatinine through inhibition of hepatic xanthine oxidase and upregulation of urate transporters (ABCG2, OAT1, OAT3). It enhances antioxidant capacity via Nrf2 activation, improves intestinal barrier integrity, and enriches beneficial gut microbiota ...
Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Saira Saif, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi   +8 more
wiley   +1 more source

Constituents and Anti-Hyperuricemia Mechanism of Traditional Chinese Herbal Formulae Erding Granule

Molecules, 2019
Erding granule (EDG) is a traditional Chinese medicine that has recently been identified as having anti-hypouricemic effects. However, the active components and underlying mechanism for this new indication have not been elucidated. Therefore, we compared
Wugang Zhang, Wendi Du, Guofeng Li, Chen Zhang, Wuliang Yang, Shilin Yang, Yulin Feng, Haifang Chen   +7 more
doaj   +1 more source

Daidzein Ameliorate Hyperuricemia by Upregulating ABCG2 Expression via Activation of PPARγ and PI3K/AKT Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
Hyperuricaemia is a chronic metabolic disorder arising from impaired purine metabolism, exhibiting marked gender disparities in its prevalence. Daidzein, possessing oestrogen‐like effects, promotes uric acid excretion and improves hepatic and renal function, thereby presenting potential utility as an adjunctive therapeutic agent for hyperuricaemia ...
Zicheng Zhu, Jujie Pan, Ruixia Bao, Beibei Chen, Siyi Li, Ziyu Che, Qian Chen, Yuzheng Wu, Dan Wang, Tao Wang   +9 more
wiley   +1 more source