Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1 [PDF]
Molecules, 2018 (1) Background: Crude drugs used in traditional Japanese Kampo medicine or folk medicine are major sources of new chemical entities for drug discovery.
Yuusuke Tashiro +7 more
doaj +2 more sources
URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy [PDF]
Frontiers in ImmunologyImpaired renal urate excretion is a major mechanism underlying hyperuricemia and gout, with urate transporter 1 (URAT1), encoded by SLC22A12, playing a central role in proximal tubular urate reabsorption.
Guangtao Li, Yu Wang, Zhuoli Zhang
doaj +2 more sources
Oral L-carnitine supplementation lowers serum uric acid and is associated with renal and intestinal urate-handling responses in hyperuricemic mice [PDF]
Frontiers in NutritionIntroductionHyperuricemia (HUA) is a common metabolic disorder associated with gout, renal dysfunction, and intestinal microenvironment disturbance. Impaired urate excretion is considered a major driver of sustained HUA.
Fengyu Jin +10 more
doaj +2 more sources
Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice [PDF]
Acta Pharmaceutica Sinica B, 2018 A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the ...
Zhizhen Qin +9 more
doaj +2 more sources
A System for Discovering Novel Uricosurics Targeting Urate Transporter 1 Based on In Vitro and In Vivo Modeling [PDF]
PharmaceuticsHyperuricemia has become a global burden with the increasing prevalence and risk of associated metabolic disorders and cardiovascular diseases. Uricosurics act as a vital urate-lowering therapy by promoting uric acid excretion via the kidneys.
Xuechen Li +7 more
doaj +2 more sources
Journal of Traditional Chinese Medical Sciences, 2019 Objective: Hyperuricemia is an excess of urate in blood. The kidneys play important parts in urate excretion, which involves handling reabsorption and secretion.
Zhijian Lin, Bing Zhang
exaly +3 more sources
Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1 [PDF]
BMC Complementary and Alternative Medicine, 2019 Background ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3).
Dool-Ri Oh +7 more
doaj +2 more sources
A Possible Therapeutic Application of the Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease [PDF]
CellsThe reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2
Hidekatsu Yanai +4 more
doaj +2 more sources
Structural Basis for the Transport and Substrate Selection of Human Urate Transporter 1
Cell ReportsSummary: High serum urate levels are the major risk factor for gout. URAT1, the primary transporter for urate absorption in the kidneys, is well known as an anti-hyperuricemia drug target.
Hongwu Qian, Qiulong Tan, Jingjing He
exaly +3 more sources
Frontiers in Pharmacology, 2022 Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout.
Yu Toyoda +15 more
doaj +1 more source