Results 41 to 50 of about 113,459,886 (161)
British Journal of Clinical Pharmacology, EarlyView.Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza +12 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Solving the mysteries of urate transport: structural insights into GLUT9 and URAT1
Acta Materia MedicaRecent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport.
Mei Wang +4 more
doaj +1 more source
Insect Science, EarlyView.Prostaglandin E2 (PGE2) signaling via its receptor has integral roles in mosquito physiology, mediating fluid excretion, stimulating hindgut contractions, and in modulating uric acid levels. Together, these results uncover previously unrecognized roles of prostaglandin signaling in osmotic balance and metabolic homeostasis in mosquitoes.
Hyeogsun Kwon +3 more
wiley +1 more source
, 2019 Background: Soluble uric acid stimulates vascular smooth muscle cell (VSMC) proliferation by activating mitogen-activated protein kinases, and stimulating COX-2 and PDGF synthesis. The mechanism by which uric acid enters the VSMC is not known.
강덕희
core +1 more source
LABOUR, EarlyView.ABSTRACT This study examines a neglected aspect of industrial relations: workplace disputes in which workers are incidentally made idle because of strike actions of others. These spillover effects have received little systematic attention despite potentially accounting for a substantial share of the employment consequences of industrial conflict.
Robert A. Hart, Carl Singleton
wiley +1 more source
BMC Pediatrics, 2018 Background We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data.
Hye Ah Lee +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura +4 more
wiley +1 more source
Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system. [PDF]
, 2014 The urate transporter, GLUT9, is responsible for the basolateral transport of urate in the proximal tubule of human kidneys and in the placenta, playing a central role in uric acid homeostasis.
Surbek, D.V. +41 more
core +3 more sources
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source