Results 61 to 70 of about 113,459,886 (161)

Reprogramming Native Cryptic Plasmids Enables Antibiotic‐Selection‐Free Urate Degradation by Escherichia coli Nissle 1917

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Reprogramming native cryptic plasmids of Escherichia coli Nissle 1917 enabled antibiotic‐selection‐free and oxygen‐adaptive urate degradation. The engineered strain reduced uric acid levels and alleviated hyperuricemia‐associated renal and inflammatory abnormalities in mice, supporting endogenous plasmid engineering as a strategy for live ...
Yuan Chi, Shiying Wu, Fei Lin, Tingwen Fan, Hongwei Liu, Huaiyi Yang   +5 more
wiley   +1 more source

Nature of urate transport in isolated rabbit proximal tubules

, 1981
Unidirectional fluxes of [14C]-urate from bath to lumen and from lumen to bath were measured in isolated perfused rabbit proximal tubules. The absorption of urate from the perfusate was small in magnitude and relatively insensitive to alteration by ...
R. Edwards, A. Shimomura, R. Tanner, J. Grantham, A. Chonko   +4 more
core   +1 more source

Anti-hyperuricemic effects of Ampelopsis grossedentata extract and its major component dihydromyricetin via targeted regulation of uric acid metabolism

Food Science and Human Wellness
Hyperuricemia (HUA), a prevalent metabolic disorder, is increasingly recognized as a critical contributor to the onset and progression of various chronic diseases, including cardiovascular and renal conditions.
Ruilong Li, Huimin Xue, Guanghe Fan, Fang Liu, Xiping Kang, Wei Lan, Yilin You   +6 more
doaj   +1 more source

Weighted Single‐Step GWAS Reveals Genetic Mechanisms Underlying Pregnancy Loss in Early Nellore Heifers

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Pregnancy loss (PL) affects reproductive efficiency in beef cattle, yet its genetic architecture remains poorly understood in Bos indicus populations. Here, PL was defined as failure from pregnancy diagnosis to calving, capturing a window approximately 60 days after the breeding season.
Flávia C. Bis, Nedenia Bonvino Stafuzza, Elisângela Chicaroni de Mattos, Angélica Simone Cravo Pereira, José Bento Sterman Ferraz, Fernando Baldi, Sabrina T. Amorim   +6 more
wiley   +1 more source

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

, 2005
Contains fulltext : 47658.pdf (Publisher’s version ) (Closed access)The end product of human purine metabolism is urate, which is produced primarily in the liver and excreted by the kidney through a well-defined basolateral blood-to ...
Russel, F.G.M., Smeets, P.H.E., Aubel, R.A.M.H. van, Heuvel, J.J.T.M.   +3 more
core   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
Allan Struthers, Jacob George, George, Jacob, Struthers, Allan   +3 more
core   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, Volume 67, Issue 10, Page 5042-5074, October 2026.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter

, 2001
Elevated serum levels of uric acid have been associated with an increased risk for gout, hypertension, cardiovascular disease, and renal failure. The molecular mechanisms for the diminished excretion of urate in these disorders, however, remain poorly ...
Michael S. Lipkowitz, Edgar Leal-Pinto, Leal-Pinto, E, Najfeld, V, Rappoport, Joshua, Joshua Z. Rappoport, Ruth G. Abramson, Abramson, RG, Lipkowitz, MS, Vesna Najfeld   +9 more
core   +1 more source

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

How URAT1 inhibitors can shape the future of chronic gout treatment: a narrative review of uricosurics past and present [PDF]

Exploration of Musculoskeletal Diseases
Gout is a common inflammatory arthritis preceded by chronically elevated levels of serum urate. In addition to leading to gouty flares, hyperuricemia can result in stone-like deposits of monosodium urate crystals (tophi) being deposited in joints and ...
Robert T. Keenan, Zancong Shen, Shunqi Yan, Li-Tain Yeh, Michael H. Pillinger   +4 more
doaj   +1 more source