Results 71 to 80 of about 113,459,886 (161)
Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.Clinical and translational readiness of IL‐6 measurement in HFrEF. ABSTRACT Background Interleukin‐6 (IL‐6) is frequently measured in heart failure with reduced ejection fraction (HFrEF), but its clinical utility remains unclear. Objectives To assess IL‐6 as a biomarker in HFrEF, with emphasis on the effect of treatments (pharmacodynamics) and ...
Yongxin Ye +11 more
wiley +1 more source
Ultrafast python‐integrated single‐entity electrochemical sensor for detecting glycated albumin
The FEBS Journal, Volume 293, Issue 19, Page 5898-5907, October 2026.Traditional biosensors suffer from the fact that recognition receptors are immobilised and that they denature on electrodes. Instead here we use receptors freely in solution, minimising surface compression and preserving activity to boost signal efficiency. Python‐driven processing turns the electrochemical response into a rapid, robust readout.
Zihni Onur Uygun
wiley +1 more source
Regulation of Urate Homeostasis by Membrane Transporters
Uric acid is the final purine metabolite in humans. Serum urate levels are regulated by a balance between urate production, mainly in the liver, and its excretion via the kidneys and small intestine.
Hirotaka Matsuo +5 more
core +1 more source
, 2008 Contains fulltext : 70432.pdf (Publisher’s version ) (Open Access)BACKGROUND AND PURPOSE: The xanthine oxidase inhibitors allopurinol and oxypurinol are used to treat hyperuricaemia, whereas loop and thiazide diuretics can cause ...
Koenderink, J.B. +7 more
core +1 more source
Frontiers in NutritionHyperuricemia (HUA) is a worldwide metabolic disorder characterized by abnormally elevated serum uric acid (SUA) levels, and recent studies suggest that probiotics have potential in mitigating HUA.
Hongyu Zhang +7 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Zurampic is a US FDA approved drug for treatment of gout. However, the influence of Zurampic on pancreatic β-cells remains unclear. The study aimed to evaluate the effects of Zurampic on high uric acid-induced damage of pancreatic β ...
Ying Xin +9 more
doaj +1 more source
Interactions Between Genetic Variants in Glucose Transporter Type 9 (SLC2A9) and Dietary Habits in Serum Uric Acid Regulation [PDF]
, 2010 Aim To investigate possible interactions between genetic variants in glucose transporter type 9 (SLC2A9) gene and dietary habits in serum uric acid regulation.
Klišmanić, Zorana +5 more
core
Hyperuricemia is mainly caused by insufficient renal urate excretion. Urate transporter 1 (URAT1), an organic anion transporter, is the main protein responsible for urate reabsorption.
Fengli Yao (11682147) +11 more
core +1 more source
Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains [PDF]
, 2020 香川大学Kagawa University博士（医学）Abstract It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease.
Uemura, Naoya +2 more
core +1 more source