Results 81 to 90 of about 113,459,886 (161)

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Hypertension may be associated with renal cellular injury. Cells in distress release extracellular vesicles (EVs), and their numbers in urine may reflect renal injury. Cellular senescence, an irreversible growth arrest in response to a noxious
Adrian Santelli, In O. Sun, Alfonso Eirin, Abdelrhman M. Abumoawad, John R. Woollard, Amir Lerman, Stephen C. Textor, Amrutesh S. Puranik, Lilach O. Lerman   +8 more
doaj   +1 more source

Could Sodium-Glucose Co-Transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists Play a Role in Gout Treatment?

Pharmaceutics
Gout, a metabolic and autoinflammatory disease, is the most common form of inflammatory arthritis worldwide. Hyperuricemia may result in monosodium urate (MSU) crystals forming and depositing in joints and surrounding tissues, triggering an ...
Dan Kaufmann, Naomi Schlesinger
doaj   +1 more source

A Brief Review of Natural Products with Urate Transporter 1 Inhibition for the Treatment of Hyperuricemia. [PDF]

Evid Based Complement Alternat Med, 2022
Yuan Q, Cheng Y, Sheng R, Yuan Y, Hu M.
europepmc   +1 more source

A Possible Exquisite Crosstalk of Urate Transporter 1 With Other Urate Transporters for Chronic Kidney Disease and Cardiovascular Disease Induced by Dotinurad. [PDF]

Cardiol Res, 2023
Yanai H, Adachi H, Hakoshima M, Katsuyama H.   +3 more
europepmc   +1 more source

Mutation in Transmembrane Domain 8 of Human Urate Transporter 1 Disrupts Uric Acid Recognition and Transport. [PDF]

ACS Omega, 2022
Lan Q, Zhao Z, Liao H, Zheng F, Chen Y, Wu T, Tian Y, Pang J.   +7 more
europepmc   +1 more source

Mechanism of Action of Bifidobacterium animalis subsp. lactis YRK-12 in Alleviating Hyperuricemia [PDF]

Shipin Kexue
Objective: To explore the potential molecular mechanism by which Bifidobacterium animalis subsp. lactis YRK-12 alleviates hyperuricemia (HUA) induced by combined oral administration of inosine, guanosine and potassium oxonate in mice.
NIU Yifan, FAN Chengfei, DONG Shengsheng, HAN Dandan, GUO Jinhuan, WANG Ran, HAO Yanling
doaj   +1 more source

Urate Transporter 1 Can Be a Therapeutic Target Molecule for Chronic Kidney Disease and Diabetic Kidney Disease: A Retrospective Longitudinal Study. [PDF]

Biomedicines, 2023
Yanai H, Katsuyama H, Hakoshima M, Adachi H.   +3 more
europepmc   +1 more source

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability

Gout and hyperuricemia are metabolic diseases characterized with high serum uric acid (SUA) levels that significantly impact human health. Lesinurad, a uricosuric agent, is limited to concurrent use with xanthine oxidase inhibitors (XOIs) in clinical ...
Qian Yang (300330), Peng Zhan (433925), Xiaoyu Shi (325706), Mingyu Yang (829412), Fan Yi (122665), Zhen Gao (609801), Zhenqian Wang (13929408), Jianxin Pang (6596942), Shuo Wang (143908), Shujing Xu (776233), Hui Liao (452190), Jian Zhang (1682), Fengxin Zheng (18153963), Xinyong Liu (1730737), Shenghua Gao (3501179), Tong Zhao (17215), Zhijiao Zhang (5629529), Danhui Qi (3139968), Youzhao Wang (4643197)   +18 more
core   +2 more sources

Blueberry ellagic acid attenuates potassium oxonate-induced hyperuricemia and renal injury in mice

Journal of Functional Foods
To investigate the effect of blueberry ellagic acid (BEA) on hyperuricemia, a hyperuricemia model was established in mice by intraperitoneal injection of potassium oxonate (300 mg/kg).
Yuping Zhu, Pan Yang, Jiao Xie, Chunlin Zhang, Tingyuan Ren   +4 more
doaj   +1 more source

Production Inhibition and Excretion Promotion of Urate by Fucoidan from Laminaria japonica in Adenine-Induced Hyperuricemic Mice

Marine Drugs, 2018
This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of ...
Dayan Zhang, Huazhong Liu, Ping Luo, Yanqun Li   +3 more
doaj   +1 more source