Results 101 to 110 of about 113,459,886 (161)

Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia

Scientific Reports
Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial.
Tomoaki Takata, Sosuke Taniguchi, Yukari Mae, Kana Kageyama, Yudai Fujino, Takuji Iyama, Katsuya Hikita, Takaaki Sugihara, Hajime Isomoto   +8 more
doaj   +1 more source

Structural basis for urate recognition and apigenin inhibition of human GLUT9

Urate, the physiological form of uric acid and a potent antioxidant in serum, plays a pivotal role in scavenging reactive oxygen species. Yet excessive accumulation of urate, known as hyperuricemia, is the primary risk factor for the development of gout.
Xiaofei Ge, Zilin Shen, Gaoxingyu Huang, Fang Kong, Tong Wu, Qifan Wang, Xiaojing Pan, Li Xu, Huan Wang   +8 more
core   +1 more source

Real-world use of dotinurad and one-year prescription presence by kidney function in older adults

Scientific Reports
Evidence on dotinurad, a selective urate transporter 1 inhibitor, in older adults with reduced kidney function is limited. We conducted a retrospective cohort study using the Japan Medical Data Center elderly claims database from April 2021 to February ...
Ryosuke Saiki, Masaki Tanabe, Tomohiro Murata, Daisuke Yamasaki, Shiho Ito, Kan Katayama, Kaoru Dohi   +6 more
doaj   +1 more source

Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes. [PDF]

Mol Med Rep, 2019
Zhang B, Duan M, Long B, Zhang B, Wang D, Zhang Y, Chen J, Huang X, Jiao Y, Zhu L, Zeng X.   +10 more
europepmc   +1 more source

Renal Nicotinate Handling by Urate Transporter 1: Hidden Benefits of Urate Transporter 1-Targetting Uricosuric Agents. [PDF]

Kidney360
Miyata H, Morimoto K, Hosoya T, Toyoda Y, Hosoyamada M, Takada T.   +5 more
europepmc   +1 more source

Characterization of Urate Transport System in JAR and JEG-3 Cells, Human Trophoblast-derived Cell Lines [PDF]

Urate (uric acid) is the major inert end product of purine metabolism in humans. Since it is water soluble, it requires a membranous protein called transporter for its permeation across the plasma membrane.
Ouchi, Motoshi, Fukasawa, Ichio, Fujita, Tomoe, Jutabha, Promsuk, Otani, Naoyuki, Anzai, Naohiko, Morita, Asuka, Kiuchi, Kaori, Nohara, Masakatsu   +8 more
core   +1 more source

Extra-renal role of urate transporter-1 in diabetes. [PDF]

World J Diabetes
Yang TS, Du M, Luo LY, Lin L, Luo XL.
europepmc   +1 more source

The Long-Term Effects of the Selective Inhibitor of Urate Transporter 1, Dotinurad, on Metabolic Parameters and Renal Function in Japanese Patients With Asymptomatic Hyperuricemia. [PDF]

J Clin Med Res
Yanai H, Adachi H, Hakoshima M, Katsuyama H.   +3 more
europepmc   +1 more source

Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report. [PDF]

BMC Nephrol, 2019
Furuto Y, Kawamura M, Namikawa A, Takahashi H, Shibuya Y, Mori T, Sohara E.   +6 more
europepmc   +1 more source

The Human Urate Transportosome: Evolutionary Dynamics, Molecular Mechanisms, and Pharmacogenetic Perspectives. [PDF]

Med Sci (Basel)
Dzhemileva LU, D'yakonov VA, Marshala SN, Khusnutdinova E, Deviatkin AA, Shipulin GA.   +5 more
europepmc   +1 more source