Results 91 to 100 of about 113,459,886 (161)

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies [PDF]

, 2012
Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, diabetes, and hypertension.
Iwen, Timothy J., Jutabha, Promsuk, Anzai, Naohiko, Lightner, Janet W., Miller, Bettina, Rice, Peter J., Endou, Hitoshi, Wakui, Shin, Wempe, Michael F., Iwen TJ, Rice PJ, Anzai N, Wempe MF, Endou H, Jutabha P, Wakui S, Lightner JW, Miller B   +17 more
core   +1 more source

Anti-inflammatory and uric acid lowering effects of Euodiae fructus on hyperuricemia and gout mice

Frontiers in Pharmacology
The metabolic disease hyperuricemia (HUA) is caused by presence of excessive serum uric acid (UA), which leads to an increased risk of chronic kidney disease and gout.
Zhilei Wang, Zhilei Wang, Jingwen Liu, Yu Mou, Wenhao Liao, Yuchen Li, Juan Liu, Jianyuan Tang, Jianyuan Tang   +8 more
doaj   +1 more source

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

, 2017
Contains fulltext : 182552.pdf (Publisher’s version ) (Open Access)OBJECTIVE: A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. METHODS:
Nakashima, H, Sakiyama, M, Yasujima, T, Pavelka, K, Shimizu, T, Shimizu, S, Kubo, M, Inoue, K, Shaukat, A, Kawaguchi, M, Inoue, I, Ichida, K, Nakamura, T, Takada, T, Matsuo, H, Sakurai, Y, Yuasa, H, Stiburkova, B, Merriman, TR, Nakayama, A, Hosoyamada, M, Shirahama, Y, Toyoda, Y, Kawamura, Y, Ito, T, Ooyama, H, Ooyama, K, Takahashi, A, Fujimori, S, Yamamoto, K, Eurogout Consortium, Suzuki, H, Stamp, LK, Yokoo, T, Ohkawa, Y, Ogata, H, Tokumasu, A, Kamatani, Y, Higashino, T, Okada, Y, Wakai, K, Shinomiya, N, Danjoh, I, Nakaoka, H, Hosoya, T, Kondo, T, Dalbeth, N   +46 more
core   +1 more source

Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α

, 2014
Renal tubular handling of urate is realized by a network of uptake and efflux transporters, including members of drug transporter families such as solute carrier proteins and ATP-binding cassette transporters.
Kroemer, Heyo K., Meyer zu Schwabedissen, Henriette, Feldtmann, Rico, Wolf, Stephanie, Zimmermann, Uwe, Prestin, Katharina, Meyer zu Schwabedissen, Henriette E., Hussner, Janine, Geissler, Ingrid, Rimmbach, Christian, Wolf S, Rimmbach C, Hussner J, Geissler I, Zimmermann U, Feldtmann R, Meyer zu Schwabedissen HE, Prestin K, Kroemer HK   +18 more
core   +1 more source

In silico and in vivo anti-hyperuricemic and anti-gouty arthritic effects of Adhatoda vasica extract: Forecasting drug candidates and mechanistic insights into urate transporter 1 and xanthine oxidase inhibition

Phytomedicine Plus
Adhatoda vasica is abundant in alkaloids and flavonoids that exhibit robust anti-inflammatory and antioxidant activity, underscoring its potential as a promising treatment for inflammatory ailments.
Rehnuma Tasmiyah Chowdhury, Sami Islam Pathan, Hajara Akhter, Md. Nazim Uddin, Mamtaz Sultana, Dabashes Adhikery, Md. Tazinur Rahman, Samina Akhter, Chadni Lyzu, Md. Abdurrahim   +9 more
doaj   +1 more source

The Effect of Decrease in Serum Urate for the Risk of Gout Flares During Urate-Lowering Therapy Initiation Among Chinese Male Gout Patients: A Prospective Cohort Study

, 2023
Lei Pang,1– 4,* Xiaomei Xue,1– 4,* Yuwei He,1– 4 Can Wang,1– 4 Lin Han,1– 4 Maichao Li,1– 4 Han Qi,1– 4 Changgui Li,1– 4 Jie Lu1– 4 1Shandong Provincial Clinical Research Center for Immune Diseases and Gout, the Affiliated Hospital of Qingdao ...
He Y, Li C, Han L, Wang C, Qi H, Lu J, Pang L, Xue X, Li M   +8 more
core  

Avian renal proximal tubule urate secretion is inhibited by cellular stress-induced AMP-activated protein kinase

, 2011
Urate is a potent antioxidant at high concentrations but it has also been associated with a wide variety of health risks. Plasma urate concentration is determined by ingestion, production, and urinary excretion; however, factors that regulate urate ...
J. Larry Renfro, Amy M. Bataille, Carla L. Maffeo   +2 more
core   +1 more source

Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

The Journal of Clinical Investigation
BACKGROUND Hyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODS We evaluated the association between ...
Wataru Fujii, Osamu Yamazaki, Daigoro Hirohama, Ken Kaseda, Emiko Kuribayashi-Okuma, Motonori Tsuji, Makoto Hosoyamada, Yuta Kochi, Shigeru Shibata   +8 more
doaj   +1 more source

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney

, 2018
International audienceUric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function
Koesters, Robert, Bonny, Olivier, Seuwen, K., Koesters, R., Auberson, M., Seuwen, Klaus, Stoudmann, C., Stadelmann, Sophie, Thorens, B., Auberson, Muriel, Stadelmann, S., Bonny, O., Stoudmann, Candice, Thorens, Bernard, Auberson M, Stoudmann C, Seuwen K, Thorens B, Stadelmann S, Koesters R, Bonny O   +20 more
core   +1 more source

Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate. [PDF]

NPJ Sci Food, 2020
Toyoda Y, Takada T, Saito H, Hirata H, Ota-Kontani A, Kobayashi N, Tsuchiya Y, Suzuki H.   +7 more
europepmc   +1 more source