Results 51 to 60 of about 113,459,886 (161)

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

, 2008
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200 500 mu M) compared with other mammals (3-120 mu M)(1).
Ralston, Stuart H., Joanne Morgan, Tatjana Skaric-Juric, Polasek, Ozren, Harry Campbell, Marijana Pericic, Shu, Xinhua, Morris, Andrew D., Knott, Sara A., Morgan, Joanne, Nina Smolej-Narancic, Pericic, Marijana, Palmer, Colin N.A., Branka Janicijevic, Nicholas D Hastie, Aringer, Martin, Veronique Vitart, Ivana Kolcic, Paul M McKeigue, Zgaga, Lina, Tenesa, Albert, Rudan, Igor, Kolcic, Ivana, McKeigue, Paul M., Graessler, Juergen, Marinaki, Anthony, Louise A Donnelly, Gray, Nicola K., Barbara Gorgoni, Richardson, William A., Pavao Rudan, Anthony Marinaki, Colin NA Palmer, Juergen Graessler, Susan Campbell, Kimber, Charley H., Andrew D Morris, Floyd, James, Wilson, James F., Hayward, Caroline, Campbell, Harry, Wild, Sarah H., Sara A Knott, Barac-Lauc, Lovorka, William A Richardson, Smolej-Narancic, Nina, Irena Martinovic Klaric, Vitart, Veronique, Campbell, Susan, James F Wilson, Lynette D Fairbanks, Biloglav, Zrinka, Peter Hohenstein, Skaric-Juric, Tatjana, Lina Zgaga, Stuart H Ralston, Martin Aringer, Klaric, Irena Martinovic, James Floyd, Alan F Wright, Ozren Polasek, Philip L Riches, Hohenstein, Peter, Hastie, Nicholas D., Fairbanks, Lynette D., Xinhua Shu, Janicijevic, Branka, Caroline Hayward, Nicola K Gray, Donnelly, Louise A., Igor Rudan, Zrinka Biloglav, Wright, Alan F., Albert Tenesa, Sarah H Wild, Charley H Kimber, Riches, Philip L., Gorgoni, Barbara, Palmer, Colin N. A.; id_orcid, Rudan, Pavao, Lovorka Barac-Lauc   +80 more
core   +1 more source

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Cell Discovery
Gout, a common and painful disease, stems from hyperuricemia, where elevated blood urate levels lead to urate crystal formation in joints and kidneys. The human urate transporter 1 (hURAT1) plays a critical role in urate homeostasis by facilitating urate
Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H. Eric Xu   +15 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Food-based modulation of intestinal urate handling in the context of systemic purine metabolism: An integrated framework linking purine bioaccessibility, epithelial transport, microbial catabolism, and barrier resilience

Journal of Functional Foods
Approximately one-third of human urate disposal occurs through the intestine, where dietary purine release, epithelial transport, microbial catabolism, and barrier homeostasis jointly shape systemic urate balance.
Jike Shuai, Yunxuan Li, Ziyang Deng, Danying Chen, Donghong Liu, Shiguo Chen, Xingqian Ye, Haibo Pan   +7 more
doaj   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

MarR homologs with urate-binding signature [PDF]

, 2011
Bacteria that associate with living hosts require intricate mechanisms to detect and respond to host defenses. Part of the early host defense against invading bacteria is the production of reactive oxygen species, and xanthine oxidase is one of the main ...
Anne Grove, Inoka C. Perera, Grove, Anne, Perera, Inoka C.   +3 more
core   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate

, 2015
To investigate the contributions towards hyperuricaemia of known risk factors, focusing on fractional (renal) clearance of urate (FCU) and variation in the ATP-binding cassette transporter, sub-family G 2 (ABCG2) gene.The contributions of age, sex ...
Kannangara, DR, Stamp, LK, Day, RO, Phipps-Green, AJ, Merriman, TR, Williams, KM, Graham, GG, Dalbeth, N   +7 more
core   +1 more source

Enhancement of Androgen Action in the Kidneys of Transgenic Mice Harboring the Mutant Human UMOD Gene

Journal of Pharmacological Sciences, 2011
Uromodulin storage diseases are characterized by hyperuricemia of underexcretion type and renal insufficiency. Although these diseases are caused by mutations in the UMOD gene that encodes the kidney-specific glycoprotein uromodulin, the effect of ...
Yuichi Takiue, Makoto Hosoyamada, Masaki Kimura, Hidetsugu Saito   +3 more
doaj   +1 more source

Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population. [PDF]

PLoS ONE, 2012
BACKGROUND: Glucose transporter 9 (GLUT9) is a high-capacity/low-affinity urate transporter. To date, several recent genome-wide association studies (GWAS) and follow-up studies have identified genetic variants of SLC2A9 associated with urate ...
Changgui Li, Nan Chu, Binbin Wang, Jing Wang, Jian Luan, Lin Han, Dongmei Meng, Yunlong Wang, Peisu Suo, Longfei Cheng, Xu Ma, Zhimin Miao, Shiguo Liu   +12 more
doaj   +1 more source