Results 21 to 30 of about 113,459,886 (161)

Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats

Journal of Ginseng Research, 2021
Background: Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders.
Yoon-Young Sung, Heung Joo Yuk, Dong-Seon Kim   +2 more
doaj   +1 more source

Genetic and Physiological Effects of Insulin on Human Urate Homeostasis

Frontiers in Physiology, 2021
Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of genetic variation in
Asim K. Mandal, Megan P. Leask, Megan P. Leask, Christopher Estiverne, Hyon K. Choi, Tony R. Merriman, Tony R. Merriman, David B. Mount, David B. Mount   +8 more
doaj   +1 more source

The renal urate transporter SLC17A1 locus: confirmation of association with gout [PDF]

, 2012
Introduction: Two major gout-causing genes have been identified, the urate transport genes SLC2A9 and ABCG2. Variation within the SLC17A1 locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been ...
Jade E Hollis-Moffatt, Amanda J Phipps-Green, Gregory T Jones, Chapman, Brett, Harrison, Andrew A., Nicola Dalbeth, Andre van Rij, Montgomery, Grant W., van Rij, Andre, Phipps-Green, Amanda J., Merriman, Tony R., Dalbeth, Nicola, Hollis-Moffatt, Jade E., Jones, Peter B., Jones, Gregory T., Stamp, Lisa K., Brett Chapman, Peter J Gow, Lisa K Stamp, John Highton, Highton, John, Tony R Merriman, Gow, Peter J., Peter B Jones, Grant W Montgomery, Andrew A Harrison   +25 more
core   +1 more source

Modulation of Urate Transport by Drugs

, 2021
Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations ...
Péter Tátrai, Franciska Erdő, Gabriella Dörnyei, Péter Krajcsi   +3 more
core   +1 more source

Fructus Gardenia Extract Ameliorates Oxonate-Induced Hyperuricemia with Renal Dysfunction in Mice by Regulating Organic Ion Transporters and mOIT3

Molecules, 2013
The potent anti-hyperuricemia activities of Fructus Gardenia Extract (FGE) have been well reported. The aim of this study was to evaluate the uricosuric and nephro-protective effects of FGE and explore its possible mechanisms of action in oxonate-induced
Hui Ji, Lin-Lin Wei, Ming-Xing Miao, Jing Ji, Ji-Xiao Zhu, Qing-Hua Hu   +5 more
doaj   +1 more source

Morin Improves Urate Excretion and Kidney Function through Regulation of Renal Organic Ion Transporters in Hyperuricemic Mice

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Morin (3,5,7,2′,4′-pentahydroxyflavone), a plant-derived flavonoid, has beneficial effects in animals with various diseases including hyperuricemia and renal dysfunction.
Cai-Ping Wang, Xing Wang, Xian Zhang, Yun-Wei Shi, Lei Liu, Ling-Dong Kong   +5 more
doaj   +1 more source

The Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway

Frontiers in Pharmacology, 2021
Sonneratia apetala Buch-Ham., an exotic mangrove species with antidiabetic, antibacterial, and antioxidant capacities, mainly distributes in the southeast coastal areas in China.
Yu-Lin Wu, Jin-Fen Chen, Lin-Yun Jiang, Xiao-Li Wu, Yu-Hong Liu, Chang-Jun Gao, Chang-Jun Gao, Yan Wu, Xiao-Qing Yi, Zi-Ren Su, Jian Cai, Jian Cai, Jian-Nan Chen   +12 more
doaj   +1 more source

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice

Frontiers in Pharmacology, 2019
Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria.
Ruixia Bao, Mengyang Liu, Dan Wang, Shaoshi Wen, Haiyang Yu, Yi Zhong, Zheng Li, Yi Zhang, Tao Wang   +8 more
doaj   +1 more source

Mechanism of Action of Limosilactobacillus fermentum FOSU-YHD19 in Alleviating Hyperuricemia [PDF]

Shipin Kexue
Objective: To investigate the mechanism underlying the uric acid-lowering effect of Limosilactobacillus fermentum FOSU-YHD19 (L. fermentum YHD19) at the cellular level. Methods: A hyperuricemic cell model was established using HK-2 cells.
HUANG Jiayi, LU Yunhui, HUANG Fang, WU Weitong, WANG Langhong, XIONG Jie, HUANG Yanyan
doaj   +1 more source

DataSheet1_OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts.pdf

, 2022
Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout.
Nariyoshi Shinomiya (156474), Yusuke Kawamura (332412), Yu Toyoda (2826734), Yasufumi Kato (3966752), Akiyoshi Nakayama (3095856), Seiko Shimizu (12357175), Hirotaka Matsuo (3095862), Kimiyoshi Ichida (3095874), Takashi Tamura (33976), Takaaki Kondo (65891), Yasushi Kobayashi (745689), Yuki Tanahashi (7422629), Keito Morimoto (12357172), Tappei Takada (2826728), Hiroshi Suzuki (8180)   +14 more
core   +1 more source