Results 81 to 90 of about 3,983 (152)

SLC2A9 allelic variants.

, 2014
Alignment of the GLUT9 amino acids in the studied allelic variants with chimpanzee, horse, dog, mouse, rat and Xenopus paralogs.
Marketa Pavlikova (5660785), Andrea Mancikova (636858), Blanka Stibůrková (564063), Vladimir Krylov (636859), Olha Hurba (636857), Karel Pavelka (605302)   +5 more
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Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2

, 2011
Background: Elevated serum uric acid (UA) is associated with gout, hypertension, cardiovascular and renal disease. Hereditary renal hypouricemia type 1 (RHUC1) is caused by mutations in the renal tubular UA transporter URAT1 and can be complicated by ...
Sawyer, Lindsay, Wright, Alan F, S. Campbell, L. Sawyer, E. J. Holtzman, Shu, Xinhua, A. F. Wright, H. Shalev, D. Landau, X. Shu, A. J. S. Knox, D. Dinour, Campbell, Susan, B.-A. Sela, Sela, Ben-Ami, Landau, Daniel, Shalev, Hanna, Gray, Nicola K, N. K. Gray, Valsamidou, Evgenia, Holtzman, Eliezer J, Gannon, Liat, Knox, Andrew J. S., E. Valsamidou, L. Ganon, Dinour, Dganit   +25 more
core   +1 more source

The spice clove effectively ameliorated hyperuricemia and hyperuricemia-induced kidney injury in mice

Journal of Agriculture and Food Research
Clove, the dried flower bud of Syzygium aromaticum, is a global spice used in various culinary traditions. In the present study, the antihyperuricemic (anti-HUA) effect of a clove water extract (CWE) and its mechanism were investigated using a ...
Fang Wang, Lin Fang, Jin-Juan Zhang, Qian Wang, Ya Wang, Qiong Fu, Yan Hong, Yan-Yan Gao, Xiao-Li Guo, Jing Li, Xue-Long Yan, Guo-Bo Xu, Xing-Jiang Liao, Xiang Fang, Shang-Gao Liao   +14 more
doaj   +1 more source

A genetic marker of hyperuricemia predicts cardiovascular events in a meta-analysis of three cohort studies in high risk patients

, 2015
The strongest genetic marker of uric acid levels, the rs734553 SNP in the GLUT9 urate transporter gene, predicts progression to kidney failure in CKD patients and associates with systolic BP and carotid intima media thickness in family-based ...
Rizza, S., Parlongo, RM, Mallamaci, F., Spoto, B., FEDERICI, MASSIMO, Leonardis, D., Sanguedolce, M. C., Federici, M., Tripepi, G., Sanguedolce, MC, Rizza, S, Federici, M, RIZZA, STEFANO, Spoto, B, Leonardis, D, Zoccali, C, Testa, A., Tripepi, G, Trischitta, V., Zoccali, C., Prudente, S, Parlongo, R. M., Mallamaci, F, Trischitta, V, Testa, A, Prudente, S.   +25 more
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A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia

Pharmacological Research
Background: Although the intestine substantially contributes to daily urate clearance, intestinal urate-lowering strategies remain limited, particularly interventions that coordinately regulate transport, barrier integrity, inflammation, and microbial ...
Mingyuan Fan, Jiushu Yuan, Hongyan Xie, Qian Li, Dingyi Lu, Sai Zhang, Qiangyan Wang, Gang Wang, Chunguang Xie, Hong Gao   +9 more
doaj   +1 more source

Characterization of GLUT8 and GLUT9, two novel glucose transporter isoforms

, 2006
Summary Prevalence of type 2 diabetes is increasing worldwide at alarming rates, probably secondarily to that of obesity. As type 2 diabetes is characterized by blood hyperglycemia, controlling glucose entry into tissues from the bloodstream is key to ...
Widmer, M.
core  

Recurrent EIARF and PRES With Severe Renal Hypouricemia by Compound Heterozygous SLC2A9 Mutation

, 2011
Renal hypouricemia (RHU) is a hereditary disease that predisposes affected people to exercise-induced acute renal failure (EIARF). In most patients with RHU, the disorder is caused by loss-of-function mutations in SLC22A12 (solute carrier family 22 ...
Norishige Yoshikawa, Hiroshi Kaito, Hiroko Togawa, Yuko Shima, Kazumoto Iijima, Kandai Nozu, Koichi Nakanishi, Yoshimi Nozu, Masafumi Matsuo   +8 more
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Inhibiting Hepatocyte Uric Acid Synthesis and Reabsorption Ameliorates Acetaminophen-Induced Acute Liver Injury in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Acetaminophen (APAP) overdose is the most common cause of drug-induced liver injury worldwide. Uric acid (UA) is involved in sterile inflammation in many organs, but its role in APAP-induced liver injury remains elusive.
Chenxi Tang, Li Cen, Hang Zeng, Xiaofen Zhang, Peihao Liu, Yishu Chen, Xin Song, Bingru Lin, Xuequn Zhang, Chaohui Yu, Chengfu Xu   +10 more
doaj   +1 more source

Anti-hyperuricemia effect of Clerodendranthus spicatus: a molecular biology study combined with metabolomics

Scientific Reports
Hyperuricemia (HUA), a metabolic disease caused by excessive production or decreased excretion of uric acid (UA), has been reported to be closely associated with a variety of UA transporters. Clerodendranthus spicatus (C.
Zheng Zhou, Manfei Xu, Meng Bian, Anzheng Nie, Bao Sun, Chunsheng Zhu   +5 more
doaj   +1 more source

A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study

, 2014
OBJECTIVES:Hyperuricemia associates with hypertension, but it is uncertain whether this relationship is causal in nature. Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans.
Mallamaci Francesca, Sanguedolce Maria Cristina, Leonardis Daniela, Spoto Belinda, Tripepi Rocco, Pisano Anna, Zoccali Carmine, Parlongo Rosa Maria, Testa Alessandra, Tripepi Giovanni   +9 more
core   +1 more source