Results 31 to 40 of about 3,983 (152)

Alpha-mangostin counteracts hyperuricemia and renal dysfunction by inhibiting URAT1 renal transporter in insulin resistance rat model

open access: yesBeni-Suef University Journal of Basic and Applied Sciences, 2022
Background Alpha-mangostin (AM) has been shown to have hypoglycemic activity. This study aimed to analyze the effects of AM at a dose of 100 mg/kg and 200 mg/kg to alleviate hyperuricemia and renal dysfunction on high-fat/high-glucose diet and low dose ...
Vivian Soetikno   +3 more
doaj   +1 more source

Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice

open access: yesCells, 2022
Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria. The role of uric acid in the pathogenesis of pre-eclampsia remains largely unclear.
Benjamin P. Lüscher   +3 more
doaj   +1 more source

NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells

open access: yesNefrología, 2023
Background: Nuclear receptor binding protein 1 (NRBP1) and ATP-binding cassette subfamily G member 2 (ABCG2) was the gout risk gene and high-capacity urate exporter respectively.
Qiankun Zhang, Hang Fang, Zaihua Zhu
doaj   +3 more sources

Study on Lowering Uric Acid Effect and Component Analysis of Drug Food Homologous Compound Based on Zebrafish Model

open access: yesShipin gongye ke-ji, 2023
Objective: In order to explore the uric acid-lowering activity and mechanism of four traditional Chinese medicines, celery seed, dandelion, chicory and corn silk, and analysis of the main functional components with uric acid-lowering effect in these four
Lingtai JIN   +3 more
doaj   +1 more source

Lactobacillus acidophilus Fermented Dandelion Improves Hyperuricemia and Regulates Gut Microbiota

open access: yesFermentation, 2023
Foodborne prevention and treatment of hyperuricemia (HUA) has received widespread attention. Lactic acid bacteria (LAB) can improve intestinal function, while traditional medicine dandelion has the functions of detoxification and detumescence.
Qianwen Ma   +9 more
doaj   +1 more source

Fatty Acid-Rich Extract from Holothuria atra for Hyperuricemia via Expressions Modulation of GLUT9a and GLUT9b in Rat Model

open access: yesMolecules, 2023
An edible sea cucumber Holothuria atra has been hypothesized to have medicinal benefits against hyperuricemia owing to its bioactive compounds, including mono- and poly-unsaturated fatty acids. Herein, we aimed to investigate the fatty acids-rich extract
Ikhsan Ikhsan   +5 more
doaj   +1 more source

Data_Sheet_1_Interaction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders.PDF

open access: yes, 2019
Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a protective effect in neurodegenerative disorders, including Alzheimer’s Disease.
Asim K. Mandal (7525190)   +1 more
core   +1 more source

Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains [PDF]

open access: yes, 2020
香川大学Kagawa University博士(医学)Abstract It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease.
Uemura, Naoya   +2 more
core   +1 more source

Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage.

open access: yes, 2020
Glucose transport across the chondrocyte membrane is essential for chondrogenesis and the development of the skeletal system. We have previously used RT-PCR to show that fully developed human articular chondrocytes express transcripts for the GLUT1 and ...
Mobasheri, A   +6 more
core   +2 more sources

The Role of Serum Uric Acid in the Prediction of Type 2 Diabetes Mellitus: Tehran Lipid and Glucose Study

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
This study aimed to examine the association between serum uric acid and incident type 2 diabetes mellitus. The study included 5719 subjects (2588 men) aged ≥ 30 years without T2DM at baseline. Multivariate Cox proportional hazard analyses were applied using SUA as continuous and categorical variables. Subjects followed up during a median follow‐up of 8.
Nahid Kord   +5 more
wiley   +1 more source

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