Results 11 to 20 of about 3,983 (152)

Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system. [PDF]

PLoS ONE, 2014
The urate transporter, GLUT9, is responsible for the basolateral transport of urate in the proximal tubule of human kidneys and in the placenta, playing a central role in uric acid homeostasis.
Benjamin Clémençon, Benjamin P Lüscher, Michael Fine, Marc U Baumann, Daniel V Surbek, Olivier Bonny, Matthias A Hediger   +6 more
doaj   +5 more sources

Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2 [PDF]

Frontiers in Genetics, 2023
Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low serum urate and overexcretion of urate in the kidney; this inheritable disorder is classified into type 1 and type 2 based on causative genes encoding physiologically ...
Yu Toyoda, Sung Kweon Cho, Sung Kweon Cho, Velibor Tasic, Kateřina Pavelcová, Jana Bohatá, Hiroshi Suzuki, Victor A. David, Jaeho Yoon, Anna Pallaiova, Jana Šaligová, Darryl Nousome, Raul Cachau, Cheryl A. Winkler, Tappei Takada, Blanka Stibůrková, Blanka Stibůrková, Blanka Stibůrková   +17 more
doaj   +2 more sources

Fucoidan from Laminaria japonica Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells

Marine Drugs, 2021
This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS ...
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang   +8 more
doaj   +2 more sources

Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate

Frontiers in Physiology, 2018
SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys, the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs ...
Anne Ruiz, Ivan Gautschi, Laurent Schild, Olivier Bonny, Olivier Bonny   +4 more
doaj   +2 more sources

The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program

SLAS Discovery
GLUT9/SLC2A9 is a urate transporter and takes a fundamental role in the maintenance of normal serum urate levels. GLUT9 is the sole transporter of reabsorbed urate from renal epithelial cells to blood, thus making it an ideal pharmacological target for ...
Antje Pommereau, Francesca Sassone, Alessandro Poli, Marcella De Silvestris, Lia Scarabottolo, Yasmin Zuschlag, Thomas Licher, Felix Bärenz   +7 more
doaj   +2 more sources

Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson’s Disease Models

Frontiers in Molecular Neuroscience, 2018
Considerable evidence has shown that elevated plasma or cerebrospinal fluid (CSF) urate levels correlated with a reduced risk of Parkinson’s disease (PD).
Mingxia Bi, Qian Jiao, Xixun Du, Hong Jiang   +3 more
doaj   +2 more sources

Structural basis for urate recognition and apigenin inhibition of human GLUT9

Nature Communications
Urate, the physiological form of uric acid and a potent antioxidant in serum, plays a pivotal role in scavenging reactive oxygen species. Yet excessive accumulation of urate, known as hyperuricemia, is the primary risk factor for the development of gout.
Zilin Shen, Li Xu, Tong Wu, Huan Wang, Qifan Wang, Xiaofei Ge, Fang Kong, Gaoxingyu Huang, Xiaojing Pan   +8 more
doaj   +2 more sources

Structural basis of urate transport by glucose transporter 9

Cell Reports
Summary: Glucose transporter 9 (GLUT9) is a critical urate transporter involved in renal reabsorption, playing a pivotal role in regulating physiological urate levels and representing a potential therapeutic target for gout.
Daiki Matsushita, Yu Toyoda, Yongchan Lee, Maeda Aoi, Hirotaka Matsuo, Tappei Takada, Tomohiro Nishizawa   +6 more
doaj   +2 more sources

The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.

PLoS Genetics, 2007
High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality.
Siguang Li, Serena Sanna, Andrea Maschio, Fabio Busonero, Gianluca Usala, Antonella Mulas, Sandra Lai, Mariano Dei, Marco Orrù, Giuseppe Albai, Stefania Bandinelli, David Schlessinger, Edward Lakatta, Angelo Scuteri, Samer S Najjar, Jack Guralnik, Silvia Naitza, Laura Crisponi, Antonio Cao, Gonçalo Abecasis, Luigi Ferrucci, Manuela Uda, Wei-Min Chen, Ramaiah Nagaraja   +23 more
doaj   +2 more sources

Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population. [PDF]

PLoS ONE, 2012
BACKGROUND: Glucose transporter 9 (GLUT9) is a high-capacity/low-affinity urate transporter. To date, several recent genome-wide association studies (GWAS) and follow-up studies have identified genetic variants of SLC2A9 associated with urate ...
Changgui Li, Nan Chu, Binbin Wang, Jing Wang, Jian Luan, Lin Han, Dongmei Meng, Yunlong Wang, Peisu Suo, Longfei Cheng, Xu Ma, Zhimin Miao, Shiguo Liu   +12 more
doaj   +2 more sources