Results 21 to 30 of about 3,983 (152)

Complex analysis of urate transporters SLC2A9, SLC22A12 and functional characterization of non-synonymous allelic variants of GLUT9 in the Czech population: no evidence of effect on hyperuricemia and gout.

PLoS ONE, 2014
ObjectiveUsing European descent Czech populations, we performed a study of SLC2A9 and SLC22A12 genes previously identified as being associated with serum uric acid concentrations and gout.
Olha Hurba, Andrea Mancikova, Vladimir Krylov, Marketa Pavlikova, Karel Pavelka, Blanka Stibůrková   +5 more
doaj   +2 more sources

Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids

Foods, 2022
Hyperuricemia (HUA), characterized by abnormal serum uric acid (UA) levels, is recognized as an important risk factor for hyperuricemic nephropathy (HN), which is strongly linked to gut microbiota.
Yongmei Li, Lu Li, Jinhong Tian, Fengxin Zheng, Hui Liao, Zean Zhao, Yanyu Chen, Jianxin Pang, Ting Wu   +8 more
doaj   +2 more sources

Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9

Frontiers in Pharmacology, 2018
Ganoderma applanatum (G. applanatum) dispels wind to eliminate dampness and exhibited nephron- and liver-protective effects as noted in Chinese herbal classic literature; it might also affect hyperuricemia. Therefore, we examined the hypouricemia effects
Tianqiao Yong, Tianqiao Yong, Shaodan Chen, Shaodan Chen, Yizhen Xie, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Chunwei Jiao, Dan Zuo   +10 more
doaj   +3 more sources

Hirudin Attenuates Uric Acid-Induced Renal Tubular Injury via TNFRSF6B-Mediated Suppression of NF-κB Signaling. [PDF]

Pharmacol Res Perspect
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Zhao Y, Qin Y, He L, Luo H, Mo Y, Zhou W, He H, Zhou G, Liu X.   +8 more
europepmc   +2 more sources

Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption. [PDF]

Chem Biol Drug Des
The graphical abstract illustrates the action mechanisms through which PPE alleviates HUA by inhibiting XOD activity, and by suppressing the PI3K‐AKT signaling pathway to downregulate the expression of the urate reabsorption transporters URAT1 and GLUT9, thereby promoting renal UA excretion and attenuating renal injury.
Yin Z, Liang S, Yang G, Guo P, Wang C, Han Q, Song X.   +6 more
europepmc   +2 more sources

Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Communications Biology
Decreased renal uric acid excretion is a major contributor to hyperuricemia (HUA), but its underlying mechanism remains unclear. Here, we identify cathepsin B (CTSB) as a key regulator of urate handling in HUA.
Huagang Lin, Linjing Nie, Deping Wu, Dexian Zhang, Rui Peng, Sijie Tao, Zhibin Ye, Sibo Zhu, Maoqing Ye, Jing Xiao   +9 more
doaj   +2 more sources

<i>Camellia oleifera</i> Seed Cake Extract Ameliorates Hyperuricemia and Renal Injury by Modulating Uric Acid Metabolism, Nrf2/Keap1 Pathway, and NLRP3 Inflammasome in Mice. [PDF]

Food Sci Nutr
Protective mechanisms of Camellia oleifera seed cake extract (SCE) against hyperuricemia and renal injury via modulation of uric acid metabolism, Nrf2/Keap1 signaling, and NLRP3 inflammasome activation. ABSTRACT Camellia oleifera seed cake is a major byproduct of the oil industry, often underutilized despite its richness in bioactive compounds.
Mai L, Xie Y, Zhang Y, Ni C, Xu Y, Xu L, Lin G, Lin Y, Su Z, Wang J, Ren M.   +10 more
europepmc   +2 more sources

DataSheet1_Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2.PDF

, 2023
Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low serum urate and overexcretion of urate in the kidney; this inheritable disorder is classified into type 1 and type 2 based on causative genes encoding physiologically ...
Jaeho Yoon (211718), Yu Toyoda (2826734), Jana Bohatá (11108907), Anna Pallaiova (14434167), Velibor Tasic (191539), Jana Šaligová (14434170), Darryl Nousome (525651), Sung Kweon Cho (14434161), Victor A. David (14434164), Cheryl A. Winkler (7923875), Blanka Stibůrková (564063), Tappei Takada (2826728), Raul Cachau (14434173), Kateřina Pavelcová (9310184), Hiroshi Suzuki (8180)   +14 more
core   +1 more source

Transporter-centric view of urate metabolism: From genome-wide association study to pathophysiology

Journal of Physical Fitness and Sports Medicine, 2012
While urate is an important anti-oxidant molecule in the body, high plasma levels of urate cause morbidity including urate crystal deposition in joints (gout) and stone formation in the urinary tract. Because urate is an end product of purine metabolism,
Hiroyuki Sakurai
doaj   +1 more source

Genetic and Physiological Effects of Insulin on Human Urate Homeostasis

Frontiers in Physiology, 2021
Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of genetic variation in
Asim K. Mandal, Megan P. Leask, Megan P. Leask, Christopher Estiverne, Hyon K. Choi, Tony R. Merriman, Tony R. Merriman, David B. Mount, David B. Mount   +8 more
doaj   +1 more source