The Stiff Joint: Comparative Evaluation of Monotherapy and Combination Therapy With Urate Lowering Agents in Managing Acute Gout [PDF]
, 2023 Okelue E Okobi +11 more
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Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley +1 more source
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
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Uric Acid, Arterial Stiffness and Blood Pressure: A Population‐Based Cohort Study
Health Science Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background and Aim Serum uric acid (SUA) has long been linked to elevated blood pressure (BP) in observational clinical studies. Nonetheless, data regarding the correlation between SUA and BP are controversial in randomized controlled trials and mendelian randomization research.
Lijun Li +5 more
wiley +1 more source
Current issues in the practical use of allopurinol in patients with gout and hyperuricemia
Современная ревматологияThe cornerstone of the treatment of gout and hyperuricemia (HU) is the use of urate-lowering drugs, primarily xanthine oxidase inhibitors. Allopurinol, which has been used to treat gout for six decades, is the first line urate-lowering therapy (ULT ...
M. S. Eliseev
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The genetics of gout: towards personalised medicine?
BMC Medicine, 2017 Over the last decade, there have been major advances in the understanding of the genetic basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering therapy.
Nicola Dalbeth +2 more
doaj +1 more source
Development of a multivariable improvement measure for gout
Arthritis Research & Therapy, 2020 Background Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.
Naomi Schlesinger +3 more
doaj +1 more source
Impact of chronic diuretic treatment on glucose homeostasis [PDF]
, 2013 Background The use of diuretics for hypertension has been associated with unfavorable changes in cardiovascular risk factors, such as uric acid and glucose tolerance, though the findings in the literature are contradictory.
AMODIO, Emanuele +9 more
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AB0920 APPLICATION OF THE EULAR 2016 GUIDELINES FOR URATE-LOWERING THERAPY IN CLINICAL PRACTICE (DATA OF A SIX-MONTH PROSPECTIVE STUDY) [PDF]
, 2020 M. N. Chikina +2 more
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Association Between Urate-Lowering Therapies and Cognitive Decline in Community-Dwelling Older Adults: A Post-Hoc Analysis of the MAPT Study. [PDF]
, 2021 Luc MOLET-BENHAMOU +3 more
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