Results 101 to 110 of about 38,184 (196)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, Volume 20, Issue 11, Page 2584-2610, November 2026.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Treatment approaches and adherence to urate-lowering therapy for patients with gout

, 2017
Thanda Aung,* Gihyun Myung,* John D FitzGerald Division of Rheumatology/Department of Internal Medicine, University of California, Los Angeles, Los Angeles, CA, USA *These authors contributed equally to this work Abstract: Gout is the most common ...
FitzGerald JD, Myung G, Aung T
core  

Enteric Fever Presenting With Acute Bilateral Lower Limb Weakness due to Para Infectious Myopathy With Elevated Serum Creatine Kinase: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Parainfectious myopathy is a rare complication of Salmonella infection. We report an immunocompetent young patient presenting with acute bilateral lower limb weakness and markedly elevated creatine kinase. Blood cultures confirmed Salmonella sp. Prompt treatment with meropenem and azithromycin resulted in reducing CK level from 1854 to 240 U/L.
Shahbaz Khan, Talha Farooq, Syeda Fatiha Hussain, Rooma Rehan, Kainat Usman, Hammad Iftikhar, Hamna Hassan Siddiqui, Muhammad Kamal, Hammad Khan, Abbas Sikandar, Somaiya Ahmed   +10 more
wiley   +1 more source

Urate-lowering agents for asymptomatic hyperuricemia in stage 3 – 4 chronic kidney disease: Controversial role of kidney function

, 2019
Because the serum uric acid level increases as the glomerular filtration rate (GFR) decreases, hyperuricemia is associated with chronic kidney disease (CKD).
Hee Jung Jeon (3663334), Jieun Oh, Jieun Oh (783748), Dong Ho Shin, Dong Ho Shin (299513), Hee Jung Jeon   +5 more
core   +1 more source

Neuroprotective Strategies and Cell-Based Biomarkers for Manganese-Induced Toxicity in Human Neuroblastoma (SH-SY5Y) Cells

Biomolecules
Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to neurotoxicity, as observed in this study, where 100 µM of Mn was administered to the human neuroblastoma (SH-SY5Y) cell model of dopaminergic neurons in ...
Catherine M. Cahill, Sanjan S. Sarang, Rachit Bakshi, Ning Xia, Debomoy K. Lahiri, Jack T. Rogers   +5 more
doaj   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Ultrasound Findings in Symptomatic HADD of the Hand and Wrist. A Case Series of 37 Patients

Journal of Clinical Ultrasound, Volume 54, Issue 9, Page 2163-2176, November/December 2026.
Ultrasound enables accurate diagnosis of hydroxyapatite deposition disease of the hand and wrist in patients with acute, non‐traumatic pain, typically in middle‐aged women. Characteristic calcifications, often in the resorptive phase, support diagnosis, while radiography may confirm findings without the need for advanced imaging.
Marco Becciolini, Riccardo Picasso, Antonio Corvino, Federico Zaottini   +3 more
wiley   +1 more source

Reprogramming Native Cryptic Plasmids Enables Antibiotic‐Selection‐Free Urate Degradation by Escherichia coli Nissle 1917

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Reprogramming native cryptic plasmids of Escherichia coli Nissle 1917 enabled antibiotic‐selection‐free and oxygen‐adaptive urate degradation. The engineered strain reduced uric acid levels and alleviated hyperuricemia‐associated renal and inflammatory abnormalities in mice, supporting endogenous plasmid engineering as a strategy for live ...
Yuan Chi, Shiying Wu, Fei Lin, Tingwen Fan, Hongwei Liu, Huaiyi Yang   +5 more
wiley   +1 more source

Urate transport in brush-border membrane of human kidney

, 1994
Mechanisms of urate transport were investigated in human renal brush-border membrane vesicles. The imposition of an outwardly directed Cl- gradient, in voltage-clamp and pH-clamp conditions, stimulated [14C]urate uptake.
B. Guisan, D. Werner, F. Roch-Ramel
core   +1 more source

Adapting an Interprofessional Medication Adherence Program for Gout (IMAP‐Gout): A Theory‐Informed Pre‐Implementation Analysis Using the Theoretical Domains Framework (TDF)

International Journal of Rheumatic Diseases, Volume 29, Issue 11, November 2026.
ABSTRACT Introduction Adherence rates to urate lowering therapy in gout remain low. Successfully implemented in Switzerland, the Interprofessional Medication Adherence Program (IMAP) supports medication adherence through an ambulatory‐based model of care that includes pharmacists, motivational interviewing, and electronic adherence monitoring. We aimed
Fatima Tahir, Hossai Gul, Sacha Bossina, Fatima Rezae, David Martens, Helene Rickard, Ayano Kelly   +6 more
wiley   +1 more source