Results 91 to 100 of about 38,184 (196)

Dual‐energy CT in gout – A review of current concepts and applications

Journal of Medical Radiation Sciences, 2017
Dual‐energy computed tomography (DECT) is a relatively recent development in the imaging of gouty arthritis. Its availability and usage have become increasingly widespread in recent years.
Hong Chou, Teck Yew Chin, Wilfred C. G. Peh   +2 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Nature of urate transport in isolated rabbit proximal tubules

, 1981
Unidirectional fluxes of [14C]-urate from bath to lumen and from lumen to bath were measured in isolated perfused rabbit proximal tubules. The absorption of urate from the perfusate was small in magnitude and relatively insensitive to alteration by ...
R. Edwards, A. Shimomura, R. Tanner, J. Grantham, A. Chonko   +4 more
core   +1 more source

Urate-lowering therapy in maintenance hemodialysis: focusing on gout burden rather than serum urate alone

Renal Replacement Therapy
Background Whether asymptomatic hyperuricemia should trigger pharmacologic intervention in maintenance hemodialysis remains unresolved. This question differs fundamentally from hyperuricemia management in the general population or in nondialysis chronic ...
Yoshitaka Furuto, Daiki Yoshino, Akio Namikawa, Dai Sato, Yuko Shibuya   +4 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Inactivation of a Thiol-Dependent Enzyme by Urate Hydroperoxide [PDF]

, 2015
There are links between high serum urate (hyperuricemia) and many inflammatory diseases, yet the mechanism is obscure. Urate, the product of purine and ATP break down, builds up in plasma because humans lack the enzyme uricase to convert it to allantoin,
Hamzah, Melanie Rosina
core   +1 more source

Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes

Communications Medicine
Background Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate ...
Zhaoli Liu, Tania O. Crișan, Cancan Qi, Manoj Kumar Gupta, Xuan Liu, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Xun Jiang, Mohamad Ballan, L. Charlotte J. de Bree, Vera P. Mourits, Xu Gao, Andrea Baccarelli, Joel Schwartz, Frank Pessler, Carlos A. Guzmán, Yang Li, Mihai G. Netea, Leo A. B. Joosten, Cheng-Jian Xu   +19 more
doaj   +1 more source

Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study

Frontiers in Endocrinology
ObjectiveGout is a common inflammatory arthritis and lipid metabolism plays a crucial role in urate and gout. Potential associations between urate and gout and lipid-lowering drugs have been revealed in observational studies.
Min Liu, Na Yin, Yuhang Zhu, Aili Du, Chunyuan Cai, Pengyuan Leng   +5 more
doaj   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

Accuracy, Quality and Readability of Knee Osteoarthritis Information on Social Media (Instagram e TikTok) and Search Platforms (Google e YouTube): A Cross‐Sectional Study

Musculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Background Knee osteoarthritis (KOA) is a chronic condition with a high global prevalence, often resulting in functional decline. Faced with this, many people turn to the internet to find information about the disease and available treatments.
Rayane Quintão Castro, Giovanna Ferreira de Oliveira, Marcella Nogueira Marques, Victória Beatriz Silva, Diogo Simões Fonseca, Carla Malaguti   +5 more
wiley   +1 more source