Results 71 to 80 of about 38,184 (196)

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Soybean plant architecture influences the capacity of Telenomus podisi to parasitize Euschistus heros eggs: implications for field releases

Pest Management Science, EarlyView.
Increasing soybean plant architectural complexity reduces the ability of Telenomus podisi to parasitize Euschistus heros eggs, highlighting the need to adjust parasitoid release rates in the field according to plant complexity (arrow direction and thickness correspond to the increasing strength of the variable) . Abstract BACKGROUND Plant architectural
Nathália Graziele Falcão Fernandes, Elianara Carvalho Cardoso, João Pedro Benaci Ayusso, Lessando Moreira Gontijo   +3 more
wiley   +1 more source

Urate uptake in oocytes.

, 2014
Transport activity is expressed as % urate uptake in oocytes injected with 50 ng of cRNA encoding the wild-type or the particular analyzed allelic variants. The uptake of 100 µM [14C]urate in oocytes was measured after 30 minutes incubation.
Marketa Pavlikova (5660785), Andrea Mancikova (636858), Blanka Stibůrková (564063), Vladimir Krylov (636859), Olha Hurba (636857), Karel Pavelka (605302)   +5 more
core   +1 more source

Prostaglandin E2 (PGE2) signaling regulates fluid excretion and uric acid metabolism in the mosquito Anopheles gambiae

Insect Science, EarlyView.
Prostaglandin E2 (PGE2) signaling via its receptor has integral roles in mosquito physiology, mediating fluid excretion, stimulating hindgut contractions, and in modulating uric acid levels. Together, these results uncover previously unrecognized roles of prostaglandin signaling in osmotic balance and metabolic homeostasis in mosquitoes.
Hyeogsun Kwon, David R. Hall, Houda O. Maaroufi, Ryan C. Smith   +3 more
wiley   +1 more source

Carrier-mediated concentrative urate transport in rat renal membrane vesicles

, 1985
[2-14C]Urate uptake and efflux were studied in brush border and basolateral membrane vesicles of rat renal cortex that were exposed to 20 microM copper chloride.
M. S. Lipkowitz, R. G. Abramson
core   +1 more source

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

Cancer Science, EarlyView.
Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Takashi Matsunaga, Kenji Wakai, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Itsuki Kageyama, Megumi Hara, Takuma Furukawa, Hiroaki Ikezaki, Yuji Matsumoto, Takeshi Nishiyama, Hiroko Nakagawa‐Senda, Chihaya Koriyama, Shiroh Tanoue, Naoyuki Takashima, Etsuko Ozaki, Katsuyuki Miura, Aya Kadota, Takeshi Watanabe, Masashi Ishizu, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Issei Imoto, Isao Oze, Keitaro Matsuo, the J‐MICC Study Group   +26 more
wiley   +1 more source

Urate kinetics in hypoxanthine-guanine phosphoribosyltransferase deficiency: Their significance for the understanding of gout

, 1976
Urate production (miscible urate pool and turnover, daily production, glycine incorporation into urate) and urate excretion (24 hour urinary urate excretion on a purine free diet, renal clearances of urate and creatinine, per cent renal excretion of ...
Gordon R.B., Emmerson B.T., Johnson L.A.
core   +1 more source

Urate as a CO₃^•− Scavenger and Regulator of SOD-1 and OGG1 Enzymes: Insights from DFT, Molecular Docking, and Molecular Dynamics

Antioxidants
The potency of urate, an abundant human plasma antioxidant, in preventing oxidative damage caused by the carbonate radical anion CO3•−, was studied using quantum chemical calculations.
Ana Amić, Žiko Milanović, Denisa Mastiľák Cagardová   +2 more
doaj   +1 more source

Multisystem developmental abnormalities and insulin resistance in ADTKD‐HNF1B with the p.E105K variant: A clinical conundrum

Diabetic Medicine, EarlyView.
Abstract Aims HNF1B variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD‐HNF1B), but the phenotypic spectrum of variants of uncertain significance (VUS) remains incompletely defined. We aimed to characterise the multisystem phenotype associated with the HNF1B p.E105K variant and to examine the mechanism underlying insulin ...
YunZe Wang, KangChun Xu, PengFei Liu, Bin Wang, Yan Yang, ShanZhai Wei   +5 more
wiley   +1 more source

Genetic Variants of Serum Uric Acid and Gout: An Analysis of > 170,000 Individuals

, 2012
Background/Purpose: Gout is a common and excruciatingly painful inflammatory arthritis caused by hyperuricemia. In addition to various lifestyle risk factors, a substantial genetic predisposition to gout has long been recognized.
Gieger C, Choi H, Ciullo M, Krumsiek J, Vitart V, Curhan G, Caulfield M, Köttgen A, C Fox, Bochud M, Albrecht E, Teumer A, The Global Urate Genetics Consortium GUGC, Plenge RM, O'Seaghdha C   +14 more
core