Results 51 to 60 of about 38,184 (196)

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Evidence for Urate Hydroperoxide as an Intermediate in the Urate Oxidase Reaction

, 2016
Evidence for Urate Hydroperoxide as an Intermediate in the Urate Oxidase ...
Annamraju D. Sarma (2982873), Peter A. Tipton (1611052)   +1 more
core   +1 more source

Genetic variants related to urate and risk of Parkinson's disease [PDF]

, 2018
Introduction: Higher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients.
Gao, Xiang, Weisskopf, Marc G., Molin Wang, Eilis J. O'Reilly, Alberto Ascherio, Kim, Iris Y., Ascherio, Alberto, Michael A. Schwarzschild, Xiang Gao, Hughes, Katherine C., Wang, Molin, Iris Y. Kim, Katherine C. Hughes, Marc G. Weisskopf, Schwarzschild, Michael A., O'Reilly, Éilis J.   +15 more
core   +1 more source

Cohort Study of Repeated Measurements of Serum Urate and Risk of Incident Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Current evidence on the association between serum urate and risk of atrial fibrillation (AF) is limited by cross‐sectional designs and 1‐time measurement of serum urate.
Shanshan Li, Jin Cheng, Liufu Cui, M. Edip Gurol, Deepak L. Bhatt, Gregg C. Fonarow, Emelia J. Benjamin, Aijun Xing, YunLong Xia, Shouling Wu, Xiang Gao   +10 more
doaj   +1 more source

Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization

Frontiers in Immunology, 2023
ObjectivesOur aim was to investigate the interactive causal effects between gut microbiota and host urate metabolism and explore the underlying mechanism using genetic methods.MethodsWe extracted summary statistics from the abundance of 211 microbiota ...
Tianzhichao Hou, Tianzhichao Hou, Huajie Dai, Huajie Dai, Qi Wang, Qi Wang, Yanan Hou, Yanan Hou, Xiaoyun Zhang, Xiaoyun Zhang, Hong Lin, Hong Lin, Shuangyuan Wang, Shuangyuan Wang, Mian Li, Mian Li, Zhiyun Zhao, Zhiyun Zhao, Jieli Lu, Jieli Lu, Yu Xu, Yu Xu, Yuhong Chen, Yuhong Chen, Yanyun Gu, Yanyun Gu, Jie Zheng, Jie Zheng, Tiange Wang, Tiange Wang, Weiqing Wang, Weiqing Wang, Yufang Bi, Yufang Bi, Guang Ning, Guang Ning, Min Xu, Min Xu   +37 more
doaj   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population‐based sample of 70‐year‐olds

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta ...
Tahzeeb Fatima, Lennart T.H. Jacobsson, Silke Kern, Anna Zettergren, Kaj Blennow, Henrik Zetterberg, Lena Johansson, Mats Dehlin, Ingmar Skoog   +8 more
doaj   +1 more source

The American College of Rheumatology Updated Recommended Methods for Development of Disease Classification and Response Criteria

Arthritis &Rheumatology, EarlyView.
Disease classification criteria and response criteria are important tools in the conduct of observational studies and clinical trials for rheumatic diseases. This paper updates methodologic guidance for classification and response criteria funded, developed and/or endorsed by the American College of Rheumatology (ACR), incorporating contemporary ...
Sindhu R. Johnson, Tuhina Neogi, Amy S. Turner, Jaime Guzman, Zahi Touma   +4 more
wiley   +1 more source

Characteristics of urate influx in the rat nephron

, 1975
Permeability of the tubular epithelium to urate presented on the peritubular side was studied in anesthetized rats during mannitol diuresis by capillary microinjections of [14C]urate and [3H]inulin, [14C]PAH and [3H]inulin, or [14C]urate and [3H]PAH ...
RH Lenoir, RA Kramp
core   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source