Results 41 to 50 of about 38,184 (196)

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization

Frontiers in Genetics, 2021
BackgroundMendelian Randomization (MR) studies show conflicting causal associations of genetically predicted serum urate with cardiovascular risk factors (i.e., hypertension, diabetes, lipid profile, and kidney function).
Thitiya Lukkunaprasit, Thitiya Lukkunaprasit, Sasivimol Rattanasiri, Boonsong Ongphiphadhanakul, Gareth J. McKay, John Attia, Ammarin Thakkinstian   +6 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

The Association of Gout Flare Resolution With Physical Activity and Sleep: A Prospective Remote‐Monitoring Study

Arthritis Care &Research, EarlyView.
Objective This study aimed to determine whether gout flare resolution is associated with physical activity and sleep. These findings were intended to inform the future development of a definition for flare resolution. Methods Data from 81 participants with gout who experienced at least one flare during a six‐month prospective observational study were ...
Sarah Stewart, Boston Girven, Mia Clarke, Irene Zeng, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, David Rice, Tania Ka'ai, Karl Rudolph, Julie Collis, Nicola Kayes, Nicola Dalbeth   +12 more
wiley   +1 more source

Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study

BIO Integration
Indigo naturalis (IN), a traditional Chinese herbal medicine, shows promising potential for treating autoimmune inflammatory diseases. However, the clinical translation and application are limited by concerns regarding vascular toxicity.
Jie Liu, Chengjian Liu, Haitao Xiao, Zhiping Xu   +3 more
doaj   +1 more source

The Role of Urate in Cardiovascular Risk in Adolescents and Young Adults With Hypertension, Assessed by Pulse Wave Velocity

Frontiers in Cardiovascular Medicine, 2022
BackgroundUrate is increasingly recognized as a cardiovascular risk factor. It has been associated with hypertension, metabolic syndrome, obesity, chronic kidney disease and diabetes. Its prognostic role is less clear.
Mirjam Močnik, Sonja Golob Jančič, Martina Filipič, Nataša Marčun Varda   +3 more
doaj   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source

Urate and arteriosclerosis in primary hyperparathyroidism

, 2001
OBJECTIVE: An increased mortality due to cardiovascular disease has been reported in patients with primary hyperparathyroidism (pHPT). An association between urate and cardiovascular disease has been suggested. Metabolic abnormalities in pHPT may include
Westerdahl, Johan, Lindblom, Pia, Valdemarsson, Stig, A. Bergenfelz, Bergenfelz, Anders, J. Westerdahl, P. Lindblom, S. Valdemarsson, Bergenfelz, Anders,, Lindblom, Pia,, Westerdahl, Johan,, Valdemarsson, Stig,, Lund University.   +12 more
core   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Calcium Urate Hexahydrate

, 2016
As part of an ongoing study to investigate the diversity of uric acid salts associated with crystal deposition diseases, calcium diurate hexahydrate (CaUr2·6H2O) was prepared and characterized by single crystal X-ray diffraction.
Katherine E. Cromer (1875577), Jennifer A. Swift (1516162), Christina Capacci-Daniel (1875574), Janeth B. Presores (1875571)   +3 more
core   +1 more source