Results 21 to 30 of about 38,184 (196)

OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts

Frontiers in Pharmacology, 2022
Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout.
Yu Toyoda, Yu Toyoda, Yusuke Kawamura, Akiyoshi Nakayama, Keito Morimoto, Seiko Shimizu, Yuki Tanahashi, Takashi Tamura, Takaaki Kondo, Yasufumi Kato, Kimiyoshi Ichida, Hiroshi Suzuki, Nariyoshi Shinomiya, Yasushi Kobayashi, Tappei Takada, Hirotaka Matsuo   +15 more
doaj   +1 more source

Urolithiasis in cats: Evaluation of trends in urolith composition and risk factors (2005‐2018)

Journal of Veterinary Internal Medicine, 2021
Background Urolithiasis is an important upper and lower urinary tract disease in cats that results in morbidity and mortality. Objective To describe trends in composition of uroliths in cats and evaluate risk factors related to age, breed, sex, urolith ...
Lucy Kopecny, Carrie A. Palm, Gilad Segev, Jennifer A. Larsen, Jodi L. Westropp   +4 more
doaj   +1 more source

Production Inhibition and Excretion Promotion of Urate by Fucoidan from Laminaria japonica in Adenine-Induced Hyperuricemic Mice

Marine Drugs, 2018
This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of ...
Dayan Zhang, Huazhong Liu, Ping Luo, Yanqun Li   +3 more
doaj   +1 more source

Associations of Blood Urate Level with Glycemic Status and Other Cardiometabolic Risk Factors in Middle-Aged Women

Women's Health Reports, 2021
Background: Hyperuricemia is a risk factor of cardiovascular disease. It remains to be elucidated how blood urate level is associated with hyperglycemia in women. Methods: The participants were 4612 middle-aged Japanese female workers.
Ichiro Wakabayashi, Takashi Daimon
doaj   +1 more source

Urate responsive MarR homologs [PDF]

, 2010
Differential gene expression in response to internal and external stimuli is studied in detail to understand the intricate mechanisms underlying response to various environmental stressors in microorganisms.
Perera, Inoka Chinthana, null null, Inoka Perera   +2 more
core   +1 more source

The role of obesity, type 2 diabetes, and metabolic factors in gout: A Mendelian randomization study

Frontiers in Endocrinology, 2022
BackgroundSeveral epidemiological studies have reported a possible correlation between risk of gout and metabolic disorders including type 2 diabetes, insulin resistance, obesity, dyslipidemia, and hypertension. However, it is unclear if this association
Yang Yang, Wei Xian, Dide Wu, Zijun Huo, Shubin Hong, Yanbing Li, Haipeng Xiao   +6 more
doaj   +1 more source

Chicken blood provides a suitable meal for the sand fly Lutzomyia longipalpis and does not inhibit Leishmania development in the gut [PDF]

, 2010
Background The aim of this study was to address the role of chickens as bloodmeal sources for female Lutzomyia longipalpis and to test whether chicken blood is harmful to Leishmania parasite development within the sand flies.
Nascimento, Alexandre, Dilger, Erin, Cavalcante, Reginaldo R, Diaz-Albiter, Hector M, Alexander, Bruce, Dillon, Rod J, Sant'anna, Mauricio Rv, Bates, Paul A   +7 more
core   +3 more sources

Quality of life improvements and clinical assessments in kidney transplant recipients undergoing pegloticase treatment for uncontrolled gout: findings of the phase 4 PROTECT clinical trial

Frontiers in Immunology
IntroductionGout is 12-times more prevalent in kidney transplant (KT) recipients than in non-transplanted population. We report quality-of-life (QOL) and clinical assessment findings from the PROTECT trial examining pegloticase efficacy and safety in KT ...
Abdul Abdellatif, Lin Zhao, Katie Obermeyer, Zana Vranic, Brad A. Marder, John D. Scandling   +5 more
doaj   +1 more source

The Causal Effect of Urate Level on Female Infertility: A Mendelian Randomization Study

Metabolites
Background/Objective: This study aimed to investigate the causal relationship between urate level and female infertility using Mendelian randomization (MR) analysis.
Jiawei Sun, Ting Shen, Yining Guan, Yixin Jiang, Xiaoling Xu   +4 more
doaj   +1 more source

Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

Metabolites, 2019
We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8−14 years.
Wei Perng, Lu Tang, Peter X. K. Song, Michael Goran, Martha Maria Tellez Rojo, Alejandra Cantoral, Karen E. Peterson   +6 more
doaj   +1 more source