Results 11 to 20 of about 38,184 (196)

Modulation of genetic associations with serum urate levels by body-mass-index in humans [PDF]

open access: yes, 2015
We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants.
Döring, Angela   +999 more
core   +3 more sources

SLC2A9 is a high-capacity urate transporter in humans [PDF]

open access: yes, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M   +241 more
core   +1 more source

Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson’s Disease Models

open access: yesFrontiers in Molecular Neuroscience, 2018
Considerable evidence has shown that elevated plasma or cerebrospinal fluid (CSF) urate levels correlated with a reduced risk of Parkinson’s disease (PD).
Mingxia Bi   +3 more
doaj   +1 more source

Modulation of Urate Transport by Drugs

open access: yesPharmaceutics, 2021
Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentrations ...
Péter Tátrai   +3 more
doaj   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

open access: yes, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
Allan Struthers   +3 more
core   +1 more source

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

open access: yes, 2021
Elevated serum urate levels cause gout and correlate with cardio-metabolic diseases via poorly understood mechanisms. We performed a trans-ethnic genome-wide association study of serum urate among 457,690 individuals, identifying 183 loci (147 novel ...
Thiery, Joachim   +224 more
core   +1 more source

Association between serum uric acid and arterial stiffness in a large‐aged 40–70 years old population

open access: yesThe Journal of Clinical Hypertension, 2022
Arterial stiffness (AS), measured by arterial stiffness index (ASI), is a determinant in cardiovascular (CV) diseases. A high serum uric acid (SUA) level is a known risk factor for CV disease. The authors investigated the relationship between SUA and ASI
Alexandre Vallée
doaj   +1 more source

Construction of uricase-overproducing strains of Hansenula polymorpha and its application as biological recognition element in microbial urate biosensor

open access: yesBMC Biotechnology, 2011
Background The detection and quantification of uric acid in human physiological fluids is of great importance in the diagnosis and therapy of patients suffering from a range of disorders associated with altered purine metabolism, most notably gout and ...
Schuhmann Wolfgang   +4 more
doaj   +1 more source

Towards a more ambitious uricemia target to improve joint and cardiovascular outcomes in gout [PDF]

open access: yesExploration of Musculoskeletal Diseases, 2023
Gout is the most common inflammatory arthritis and a global health problem. In addition to joint involvement, urate crystals induce chronic inflammation, leading to increased cardiovascular risk in gout.
Enrique Calvo-Aranda   +1 more
doaj   +1 more source

Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006‐2018)

open access: yesJournal of Veterinary Internal Medicine, 2021
Background Urolithiasis is a common and often recurrent problem in dogs. Objective To evaluate trends in urolith composition in dogs and to assess risk factors for urolithiasis, including age, breed, sex, neuter status, urolith location, and bacterial ...
Lucy Kopecny   +3 more
doaj   +1 more source

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