Results 31 to 40 of about 2,566,374 (138)

Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway

Nutrition & Metabolism, 2021
Objectives The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy.
Lei Liu, Tianyi Zhao, Lizhen Shan, Ling Cao, Xiaoxia Zhu, Yu Xue   +5 more
doaj   +1 more source

Baseline Dual-Energy Computed Tomography Urate Volume Predicts Fulfillment of Gout Remission After Two Years of Urate-Lowering Therapy. [PDF]

Arthritis Care Res (Hoboken)
OBJECTIVE: This study aimed to identify variables that predict gout remission in people with erosive gout receiving urate-lowering therapy. METHODS: We analysed data from a 2-year, double-blind randomized-controlled trial of people with erosive gout ...
Tabi-Amponsah AD, Stewart S, Gamble G, Doyle AJ, Billington K, Son CN, Latto K, Stamp LK, Taylor WJ, Horne A, Dalbeth N.   +10 more
europepmc   +2 more sources

Intensive Serum Urate Lowering With Oral Urate‐Lowering Therapy for Erosive Gout: A Randomized Double‐Blind Controlled Trial

, 2021
OBJECTIVE: To determine whether intensive serum urate lowering results in improved bone erosion scores in erosive gout. METHODS: Two-year, double-blind, randomized, controlled trial of 104 participants with erosive gout on oral urate-lowering therapy ...
Lisa K. Stamp, Parshu Ram, Thrishila; id_orcid, Doyle, Anthony J, Nicola Dalbeth, Greg D. Gamble, Paul Tan, Anthony J. Doyle, Murdoch, Rachel, Mihov, Borislav, Thrishila Parshu Ram, Billington, Karen, Borislav Mihov, Gamble, Greg D, Doyle, Anthony J., Dalbeth, Nicola, Stamp, Lisa K., Horne, Anne, Tan, Paul, Stamp, Lisa K, David Bursill, Anne Horne, Gamble, Greg D., Ravi Narang, Kieran Latto, Latto, Kieran, Rachel Murdoch, Parshu Ram, Thrishila, Bursill, David, Narang, Ravi, Karen Billington   +29 more
core   +1 more source

Contentious Issues in Gout Management: The Story so Far

Open Access Rheumatology: Research and Reviews, 2021
Mohamed Talaat,1 Kyle Park,1 Naomi Schlesinger2 1Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA; 2Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08903-0019 ...
Talaat M, Park K, Schlesinger N
doaj  

Experience with canakinumab in a patient with gout and IgA nephropathy

Современная ревматология, 2019
The paper discusses the results of clinically using the interleukin-1_ inhibitor canakinumab in a patient with chronic tophaceous gout, IgA nephropathy, and chronic kidney disease with resistance to traditional anti-inflammatory drugs (colchicine ...
E. V. Ilyinykh, M. S. Eliseev
doaj   +1 more source

Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care [PDF]

, 2019
Objectives To explore patient perception of the role of a nurse-led complex package of care in facilitating engagement with urate-lowering therapies (ULTs) in the management of gout.Methods Thirty people who had participated in a randomised controlled ...
Abhishek, Abhishek, Jenkins, Wendy, Nakafero, Georgina, Latif, Zahira P., Doherty, Michael   +4 more
core   +1 more source

Variation in serum urate levels in the absence of gout and urate lowering therapy

BMC Rheumatology, 2021
Background Previous studies have noted significant variation in serum urate (sUA) levels, and it is unknown how this influences the accuracy of hyperuricemia classification based on single data points.
Andrew Shaffer, Elizabeth Rahn, Kenneth Saag, Amy Mudano, Angelo Gaffo   +4 more
doaj   +1 more source

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy [PDF]

, 2018
BACKGROUND: Previous studies that quantified the risk of fracture among patients with gout and assessed the potential effect of urate-lowering therapy have provided conflicting results. Our study aims to provide better estimates of risk by minimizing the
Mallen, Bucknall, Hider, Paskins, Roddy, Helliwell, Muller   +6 more
core   +2 more sources

Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits. [PDF]

, 2020
Objective Few studies have systematically and quantitatively addressed the impact of urate‐lowering therapy on monosodium urate (MSU) deposits. This study was undertaken to analyze the effect of lifestyle measures and conventional urate‐lowering therapy ...
Sara Bayat, Schett, Georg, Hannah Schenker, Elizabeth Araujo, Alexander Cavallaro, Araujo, Elizabeth, David Simon, Georg Schett, Bernhard Manger, Manger, Bernhard, Ellmann, Hanna, Cavallaro, Alexander, Rech, Jürgen, Herbert S. B. Baraf, Michael Lell, Arnd Kleyer, Jürgen Rech, Hanna Ellmann, Kleyer, Arnd, Baraf, Herbert S B, Baraf, Herbert S. B., Lell, Michael, Tascilar, Koray, Bayat, Sara, Koray Tascilar, Schenker, Hannah, Simon, David   +26 more
core   +1 more source

Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial

Arthritis Research & Therapy, 2022
Background Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life.
John K. Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E. Weinblatt, Jeff Peterson   +5 more
doaj   +1 more source