Results 51 to 60 of about 2,566,374 (138)

Urate-lowering therapy (ULT).

, 2015
1Answers in agreement with the 2012 American College of Rheumatology gout guidelines2participants who reported not to adjust ULT for patients with tophaceous gout based on the SUA level were excluded from other questions that were based on the concept of
Geraldo da Rocha Castelar-Pinheiro (783431), H. Ralph Schumacher Jr. (443559), Ana Beatriz Vargas-Santos (783430), Evandro Silva Freire Coutinho (107557), Naomi Schlesinger (783432), Jasvinder A. Singh (484385)   +5 more
core   +1 more source

Prospects of anti-inflammatory and urate-lowering therapy of gout: A vector from the past to the future [PDF]

, 2022
The article provides an overview of new and promising drugs aimed at anti-inflammatory and urate-lowering therapy of gout, both already registered and used in clinical practice, and at the stages of implementation or clinical research and demonstrating ...
N. L. Novichkova, A. A. Garanin
core   +1 more source

Update on the Clinical Management of Gout: A Focused Review for the Primary Care Physician

International Journal of Clinical Practice
Gout confers significant burden to patients and is often undertreated despite the availability of safe and efficacious therapies. Undertreatment likely stems from clinical providers’ concerns navigating the complexities of initiating and escalating urate-
Riya Madan, Ted R. Mikuls, Joshua F. Baker, Brian W. Coburn   +3 more
doaj   +1 more source

Urate lowering therapy in primary care: rheum for improvement [PDF]

Exploration of Musculoskeletal Diseases
Primary care physicians (PCPs) play a critical role in the management of gout worldwide. However, significant gaps in gout care persist, underscoring the need for improved approaches to its management.
Emilie Schurenberg, Edward M. Huddleston, Kenneth G. Saag   +2 more
doaj   +1 more source

The impact of urate-lowering therapy on kidney function (IMPULsKF)

, 2017
The concept of trial launched in Ukraine in 2017 with POEM design and 36-months duration is presented. It aims to investigate the impact of two target levels of urate-lowering therapy caused by hyperuricemia on kidney function and chronic kidney disease (
D.D. Ivanov
core   +1 more source

Urate lowering therapy in patients starting hemodialysis limit gout flares occurrence: ten years retrospective study. [PDF]

BMC Nephrol
Background Uncontrolled gout can cause articular impairment but is also associated with a global and cardiovascular excess mortality, especially in dialysis population.
Steelandt A, Hittinger A, Kanagaratnam L, Kazes I, Clavel P, Bolko L, Rieu P, Salmon JH.   +7 more
europepmc   +2 more sources

Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice

Frontiers in Medicine, 2020
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout.
Kateryna Pierzynowska, Kateryna Pierzynowska, Kateryna Pierzynowska, Aditi Deshpande, Nadiia Mosiichuk, Robert Terkeltaub, Paulina Szczurek, Eduardo Salido, Stefan Pierzynowski, Stefan Pierzynowski, Stefan Pierzynowski, Danica Grujic   +11 more
doaj   +1 more source

Critical appraisal of the role of pegloticase in the management of gout

Open Access Rheumatology: Research and Reviews, 2012
Hang-Korng Ea,1,2 Pascal Richette1,21Hôpital Lariboisière, Rheumatology Department, Paris, France; 2University of Paris Diderot, Sorbonne Paris Cité, Paris, FranceAbstract: Gout is a debilitating disease secondary to ...
Ea HK, Richette P
doaj  

Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data [PDF]

BackgroundInitiating urate-lowering therapy can trigger gout flares. Gout flares have been associated with a temporally increased risk of cardiovascular events.
Avery, Anthony, Choi, Hyon, Abhishek, Abhishek, McCormick, Natalie, Yokose, Chio, Mamas, Mamas, Tata, Laila, Nakafero, Georgina, Cipolletta, Edoardo   +8 more
core   +1 more source

Management of gout: Primary care approach

South African Family Practice, 2009
Great strides have been made in understanding gout as a disease over the centuries. Despite these advances, reports suggest that the management of gout is relatively sub-optimal at the primary care level.
Olufemi Omole, Gboyega A. Ogunbanjo
doaj   +1 more source