Results 61 to 70 of about 2,566,374 (138)

Urate-lowering therapy in maintenance hemodialysis: focusing on gout burden rather than serum urate alone

Renal Replacement Therapy
Background Whether asymptomatic hyperuricemia should trigger pharmacologic intervention in maintenance hemodialysis remains unresolved. This question differs fundamentally from hyperuricemia management in the general population or in nondialysis chronic ...
Yoshitaka Furuto, Daiki Yoshino, Akio Namikawa, Dai Sato, Yuko Shibuya   +4 more
doaj   +1 more source

Factors associated with initiation and persistence of urate-lowering therapy [PDF]

, 2017
Background: Gout is the most common inflammatory arthritic disease and is caused by crystal deposition secondary to persistent hyperuricemia. Etiological treatment with urate-lowering therapy (ULT) has been available since the 1950s but previous studies ...
Telg, G., Strömberg, Ulf,, Jacobsson, Lennart T. H.,, Dehlin, Mats,, Ekstrom, E. H., Petzold, Max,, Ulf Strömberg, Lennart T. H. Jacobsson, Emin Hoxha Ekström, Mats Dehlin, Max Petzold, Gunilla Telg   +11 more
core   +1 more source

Current issues in the practical use of allopurinol in patients with gout and hyperuricemia

Современная ревматология
The cornerstone of the treatment of gout and hyperuricemia (HU) is the use of urate-lowering drugs, primarily xanthine oxidase inhibitors. Allopurinol, which has been used to treat gout for six decades, is the first line urate-lowering therapy (ULT ...
M. S. Eliseev
doaj   +1 more source

The genetics of gout: towards personalised medicine?

BMC Medicine, 2017
Over the last decade, there have been major advances in the understanding of the genetic basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering therapy.
Nicola Dalbeth, Lisa K. Stamp, Tony R. Merriman   +2 more
doaj   +1 more source

Schematic of the samples selection process for association between urate-lowering therapy and risk of type 2 diabetes mellitus.

, 2019
Schematic of the samples selection process for association between urate-lowering therapy and risk of type 2 diabetes mellitus.
Hsin-Wen Chang (216673), Ya-Wen Lin (2738968), Ming-Hung Lin (4373560), Ruey-Yun Wang (384835), Yu-Ching Lan (431716)   +4 more
core   +1 more source

Kiesselbach’s area nasal septal gouty tophus with an integrated “3 + 2” diagnostic algorithm: a case report

Journal of Medical Case Reports
Background Gout, characterized by monosodium urate crystal deposition, rarely involves the nasal septum, with only a few reported cases. Such unusual presentations can mimic other conditions, necessitating prompt and accurate diagnosis.
Weikun Chen, Wanling Chen, Duanyue Guo, Ziyue Wang, Ziwen Shi, Junwei Zhong   +5 more
doaj   +1 more source

Battle of the strategies: diet versus drug therapy for gout

Современная ревматология
The best results in combating gout are achieved through a combination of diet and drug therapy. Urate-lowering therapy, which includes febuxostat, has been shown to be more effective and convenient than diet when it comes to achieving and maintaining ...
O. V. Zhelyabina, M. S. Eliseev, A. M. Lila   +2 more
doaj   +1 more source

Uricases: reflections on recent developments in the management of challenging gout patients [PDF]

Exploration of Musculoskeletal Diseases
Oral urate-lowering therapy (ULT) is key to treating gout. However, many patients receiving oral ULT do not achieve the target serum urate (SU) levels, partly because some patients cannot tolerate or have contraindications to their use, mainly due to ...
Naomi Schlesinger, Dan Kaufmann
doaj   +1 more source

A prospective clinical study on the efficacy and safety of specific uric acid adsorption hemoperfusion in removing serum uric acid from patients with refractory gout

Zhongguo shuxue zazhi
[Objective] To evaluate the efficacy and safety of the single-use hemoperfusion device (UA230) in treating refractory gout (RG) via plasma perfusion. [Methods] Thirty-four RG patients aged 18-65 years were recruited and randomly divided into a control ...
LI Ying, YANG Yuanming, JING Zhongcui, LIU Jiao, JIANG Dandan, YU Shanshan, WANG Haiyan   +6 more
doaj   +1 more source

Guideline development for the management of gout: role of combination therapy with a focus on lesinurad

Drug Design, Development and Therapy, 2017
Graeme Jones,1 Elena Panova,1 Richard Day2 1Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia; 2University of New South Wales, Medicine, St Vincent’s Hospital, Sydney, NSW, Australia Abstract: The aim of this ...
Jones G, Panova E, Day R
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