Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]
NeuropathologyABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P +3 more
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Machine learning analysis of kinematic movement features during functional tasks to discriminate chronic neck pain patients from asymptomatic controls [PDF]
Scientific ReportsThis study evaluated the discriminative potential of a machine learning model using movement features during functional tasks to distinguish between patients with non-traumatic chronic neck pain and asymptomatic controls. The study included patients with
Filippo Moggioli +9 more
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Revista de Salud Pública, 2020 Objetivo: analizar el entorno alimentario a través de la disponibilidad comercial de alimentos asociados a la salud cardiovascular y su relación con el nivel de urbanización en la localidad de La Calera. Metodología: se relevaron las características de
Vanesa Roxana Scarlatta +1 more
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Early Disclosure of Blood‐Based Biomarkers Optimizes Alzheimer's Disease Management and Treatment Initiation: the PLASMAR study [PDF]
Alzheimers DementAbstract Background Blood‐based biomarkers (BBMs) offer a cost‐effective, non‐invasive approach for detecting Alzheimer's disease (AD) pathology, but their impact on improving diagnostic certainty and patient management remains unclear. The PLASMAR study is a prospective, single‐center, blinded, randomized controlled trial assessing the effect of early
Estragués‐Gázquez I +19 more
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Effect of a Gluten-Free Diet on the Intestinal Microbiota of Women with Celiac Disease [PDF]
AntibioticsBackground/Objectives: Celiac disease (CD) is an autoimmune disorder characterized by small intestinal enteropathy triggered by gluten ingestion, often associated with gut dysbiosis. The most effective treatment is strict adherence to a gluten-free diet (
M. Mar Morcillo Serrano +8 more
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Effect of focal muscle vibration on sEMG activity during repeated elbow movements in healthy adults [PDF]
Journal of NeuroEngineering and RehabilitationBackground Focal muscle vibration (FMV) is a non-invasive intervention that can modulate neuromuscular excitability, traditionally assessed with electrostimulation-evoked responses like F-waves or H-reflexes, which can be uncomfortable and impractical ...
Carmen Cabezaolias +4 more
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Active Neurodynamic Technique at Home in Patients with Knee Osteoarthritis: An Open Single Arm Clinical Trial [PDF]
MedicinaBackground and Objectives: Knee osteoarthritis (KO) stands as the third leading cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality.
Beatriz Serrano-García +3 more
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Gut Resistome and Hearing Loss in Young Adults: A Preliminary Study on the Interplay Between Microbial Resistance and Auditory Health [PDF]
AntibioticsBackground: Hearing loss (HL) affects more than 1.5 billion people worldwide and represents a major global health concern. Recent evidence suggests that alterations in gut microbial composition and antimicrobial resistance (AMR) may be linked to ...
Julia Almazán-Catalán +9 more
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Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice [PDF]
Frontiers in PharmacologyAlzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different ...
Teresa Fontán-Baselga +9 more
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Systemic immune response alteration in patients with severe pressure ulcers [PDF]
Scientific ReportsWound healing is a dynamic process involving tissue formation, debris removal and ultimately remodeling to restore skin integrity. Although wound healing is generally successful, this process can eventually fail, leading to chronic wounds like pressure ...
Lucía Tejero Peña +11 more
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