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Urea–Aromatic Stacking and Concerted Urea Transport: Conserved Mechanisms in Urea Transporters Revealed by Molecular Dynamics

Journal of Chemical Theory and Computation, 2016
Urea transporters are membrane proteins that selectively allow urea molecules to pass through. It is not clear how these transporters allow rapid conduction of urea, a polar molecule, in spite of the presence of a hydrophobic constriction lined by aromatic rings.
Siladitya Padhi, U Deva Priyakumar
exaly   +4 more sources

Urea transporters in kidney and erythrocytes

American Journal of Physiology-Renal Physiology, 1997
Physiological and molecular data demonstrate that urea transport in kidney and erythrocytes is regulated by specific urea transporter proteins. The urea transporter in the terminal inner medullary collecting duct permits very high rates of regulated transepithelial urea transport and results in the delivery of large amounts of urea into the deepest ...
J M, Sands, R T, Timmer, R B, Gunn
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Mammalian Urea Transporters

Annual Review of Physiology, 2003
▪ Abstract  Urea plays a key role in the urine-concentrating mechanism. Physiologic and molecular data demonstrate that urea transport in kidney and red blood cells occurs by specific urea transporter proteins. Two gene families for facilitated urea transporters, UT-A and UT-B, and several urea transporter cDNA isoforms have been cloned from human ...
Jeff M Sands
exaly   +3 more sources

Gene structure of urea transporters

American Journal of Physiology - Renal Physiology, 2003
Urea plays various roles in the biology of diverse organisms. The past decade has produced new information on the molecular structure of several urea transporters in various species. Availability of DNA probes has revealed that the presence of urea transporters is not confined to the mammalian kidney but is also evident in testis and brain, raising new
Serena M Bagnasco
exaly   +3 more sources

Role and regulation of urea transporters

Pflugers Archiv European Journal of Physiology, 2005
In the past few years, significant knowledge has been gained about the physiological role and regulation of urea transporters, which have been now cloned in many species. The two major mammalian urea transporters, UT-A and UT-B, have been best studied in the kidney, where they mediate the facilitated diffusion of urea across tubular, interstitial, and ...
Serena M Bagnasco
exaly   +3 more sources

The Physiology and Evolution of Urea Transport in Fishes

Journal of Membrane Biology, 2006
This review summarizes what is currently known about urea transporters in fishes in the context of their physiology and evolution within the vertebrates. The existence of urea transporters has been investigated in red blood cells and hepatocytes of fish as well as in renal and branchial cells. Little is known about urea transport in red blood cells and
McDonald, M. D., Smith, C. P., Walsh, P. J.   +2 more
openaire   +4 more sources