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Urea Transport Mediated by Membrane Proteins of Non-urea-Transporters
Urea is generated by the urea cycle enzymes, which are mainly in the liver but are also ubiquitously expressed at low levels in other tissues of mammals. Urea is then eliminated through fluids, especially urine. Urea also serves as a readily available nitrogen source for the growth of many organisms, including plants and bacteria. Urea transporters areMinghui, Wang +2 more
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Genes and Proteins of Urea Transporters
2014A urea transporter protein in the kidney was first proposed in 1987. The first urea transporter cDNA was cloned in 1993. The SLC14a urea transporter family contains two major subgroups: SLC14a1, the UT-B urea transporter originally isolated from erythrocytes; and SLC14a2, the UT-A group originally isolated from kidney inner medulla.
Jeff M, Sands, Mitsi A, Blount
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Nephrologie, 1997
Water and urea use different pathways to cross biological membranes: channels and carriers. Numerous water channels were cloned (aquaporins); only two urea transporters are characterized in mammalians (UT2 and UT11) with sequence homologies suggesting two different carriers.
P, Ripoche, G, Rousselet
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Water and urea use different pathways to cross biological membranes: channels and carriers. Numerous water channels were cloned (aquaporins); only two urea transporters are characterized in mammalians (UT2 and UT11) with sequence homologies suggesting two different carriers.
P, Ripoche, G, Rousselet
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Urea transport in the toad bladder; Coupling of urea flows
The Journal of Membrane Biology, 1973Urea transport across amphibian membranes is influenced by interactions with the membrane, the solvent and other solutes. One case of solute interaction, that in which the two species are chemically identical, is investigated here. Because of the effects of hypertonic urea on permeability, the demonstration of interaction required consideration of the ...
P D, Lief, A, Essig
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WATER CHANNELS AND UREA TRANSPORTERS
Clinical and Experimental Pharmacology and Physiology, 1997SUMMARY1. It now appears that when water crosses an endothelium which is not fenestrated, or an epithelium with tight junctions, it does so rapidly, and with low energy cost, only if the cell membrane contains an adequate number of specific water channels, encoded by one of at least six different genes.2.
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The Journal of Physical Chemistry B, 2015
Urea transporters are a family of membrane proteins that transport urea molecules across cell membranes and play important roles in a variety of physiological processes. Although the crystal structure of bacterial urea channel dvUT has been solved, there lacks an understanding of the dynamics of urea transport in dvUT. In this study, by using molecular
Zhe, Wang +5 more
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Urea transporters are a family of membrane proteins that transport urea molecules across cell membranes and play important roles in a variety of physiological processes. Although the crystal structure of bacterial urea channel dvUT has been solved, there lacks an understanding of the dynamics of urea transport in dvUT. In this study, by using molecular
Zhe, Wang +5 more
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Molecular Mechanisms of Urea Transport
Journal of Membrane Biology, 2003Physiologic data provided evidence for specific urea transporter proteins in red blood cells and kidney inner medulla. During the past decade, molecular approaches resulted in the cloning of several urea transporter cDNA isoforms derived from two gene families: UT-A and UT-B. Polyclonal antibodies were generated to the cloned urea transporter proteins,
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Transport Characteristics of Urea Transporter-B
2014UT-B represents the major urea transporter in erythrocytes, in addition to being expressed in kidney descending vasa recta, brain, spleen, ureter, bladder, and testis. Expression of urea transporter UT-B confers high urea permeability to mammalian erythrocytes.
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The sweet side of urea transporters
American Journal of Physiology-Renal Physiology, 2012UREA IS PRODUCED AS AN END product of protein catabolism in the liver and is ultimately excreted by the kidney. However, this unique small molecule of only 60 daltons is also used by the kidney to control water balance by a complex process that involves both secretion and reabsorption of urea throughout the entire renal tubule (11).
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Biochemical Properties of Urea Transporters
2014Urea and urea transporters (UT) are critical to the production of concentrated urine and hence in maintaining body fluid balance. The UT-A1 urea transporter is the major and most important UT isoform in the kidney. Native UT-A1, expressed in the terminal inner medullary collecting duct (IMCD) epithelial cells, is a glycosylated protein with two ...
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