Results 91 to 100 of about 1,080,434 (247)

In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

BMC Chemistry, 2019
Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids.

Chemical and Pharmaceutical Bulletin, 1992
A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH: X = amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10(-6) M and inhibited Proteus mirabilis urease with an I50 of the order ...
ODAKE, Shinjiro, NAKAHASHI, Kazuaki, MORIKAWA, Tadanori, TAKEBE, Sachiko, KOBASHI, Kyoichi   +4 more
openaire   +2 more sources

Microplastic‐Induced Shifts in Soil Leachate Chemistry, Redox Response, Biochemistry, and Biofilm Dynamics

Land Degradation &Development, EarlyView.
ABSTRACT Microplastics (MPs) are increasingly recognized as soil contaminants, yet their time‐dependent associations with dissolved organic matter characteristics, redox behavior, biochemical constituents, and biofilm‐associated responses are often investigated separately.
Asli Baysal, Hasan Saygin, Pinar Kayisoglu, Sinem Karniyarik   +3 more
wiley   +1 more source

Quantum mechanical study of urease inhibition by Isatin derived sulphonyl hydrazide / Muhammad Syazan Mohammad Ariff [PDF]

, 2022
Isatin (1H-indole-2,3-dione) plays a vital role in pharmaceuticals and agriculture due to its unique properties which make Isatin one of the important heterocyclic compounds.
Mohammad Ariff, Muhammad Syazan
core  

Gramine Suppresses Myofibroblast Activation and ECM Accumulation in Renal Fibrosis by Targeting the NF‐κB/NLRP3 and TGF‐β1/Smad Pathways

Phytotherapy Research, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is driven by persistent inflammation and progressive fibrosis, leading to irreversible renal damage. Gramine (GMN), an indole alkaloid, has broad pharmacological benefits. However, its therapeutic potential against renal fibrosis remains unexplored.
Shobhit Gairola, Archana Bhatta, Tushar Mishra, Ravinder K. Kaundal   +3 more
wiley   +1 more source

محمد عبد الله عبد الكريم دراسة كفاءة مثبطات انزيم اليوريز في الترب المعاملة بمياه الصرف الصحي

مجلة علوم ذي قار, 2019
An incubation experiment was carried out to study the effect of municipal waste water on the efficiency of some urease inhibitors in soil. Waste water was collected from external basin of Hamdan industrial station, Basrah province and was passed through
محمد عبدالله
doaj  

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Benzimidazolone‐piperazine/triazole/thiadiazole/furan/thiophene conjugates: Synthesis, in vitro urease inhibition, and in silico molecular docking studies

, 2023
This study describes the synthesis, in vitro urease inhibition, and molecular docking studies of benzimidazolone derivatives incorporating the piperazine, triazole, thiadiazole, furan, thiophene, and thiosemicarbazide moieties.
Akyüz, Gülay, Emre Menteşe, Gülay Akyüz, Güven, Okan, Mustafa Emirik, Okan Güven, Emirik, Mustafa, Menteşe, Emre, Sökmen, Bahar Bilgin, Bahar Bilgin Sökmen   +9 more
core   +1 more source

Fertilizer Sustainability: A Conceptual Framework for Assessing Equitable and Sustainable Soil Inputs

Sustainable Development, EarlyView.
ABSTRACT Modern industrial agriculture is predicated largely on the production and utilization of chemical fertilizers. Although this approach has played an integral role in increasing food security in many parts of the world, the long‐term sustainability of this resource‐intensive approach is questionable.
Benjamin Wilde, Roman Hüppi, Gina Garland, Rafaela Feola Konz, Kenza Benabderrazik, William Thompson, Martin Hartmann, Bernard Vanlauwe, Kokou Kintche, Leonhard Späth, Matieyedou Konlambigue, Johanna Jacobi, Johan Six   +12 more
wiley   +1 more source

Novel indole-based sulfonate and sulfamate derivatives as potent and selective urease inhibitors targeting Helicobacter pylori: a promising therapeutic strategy

Gut Pathogens
Helicobacter pylori (H. pylori) infection is strongly associated with peptic ulcer and gastric cancer, compounded by the growing prevalence of antibiotic resistance.
Ghalia Khoder, Esra M. Mustafa, Sumera Zaib, Anil Ravi, Afnan I. Shahin, Seyed-Omar Zaraei, Nehal Rana, Hanan S. Anbar, Hafiz Saqib Ali, Shamsul Qumar, Merylin Sebastian, Ragheb Alsheikh Zein, Mohammed I. El-Gamal   +12 more
doaj   +1 more source