Concentrating human urine intrinsically inhibits urease activity
Frontiers in Environmental ScienceUrea is the dominant nitrogen compound in human urine and represents a valuable fertiliser resource if enzymatic hydrolysis can be controlled during storage and processing.
C. Parrow Melhus, B. Vinnerås, P. Simha
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Enzyme-based Colorimetric and Potentiometric Biosensor for Detecting Pb (II) Ions in Milk
Brazilian Archives of Biology and Technology, 2014 The aim of the present work was to study a simple colorimetric and potentiometric biosensor based on urease inhibition by Pb (II) ions for its estimation in milk samples.
Hardeep Kaur, Sachin Kumar, Neelam Verma
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Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening. [PDF]
Int J Mol Sci, 2023 Aniceto N +4 more
europepmc +1 more source
Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists
SmartBot, EarlyView.Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu +12 more
wiley +1 more source
Macroscopic Convective Fluid Flows Arising From Binding of Ions and Small Molecules to Proteins
Small, EarlyView.The interaction of ions or small molecules with proteins causes convective flows due to the displacement of water from the hydration shell. As shown, the replacement of the nickel ion removed from urease by EDTA pre‐treatment results in binding‐induced convective fluid flow.
Shanid Babu Shrestha +4 more
wiley +1 more source
Biochemical and Structural Studies on Urease Inhibition. A Nickel-Dependent Virulence Factor [PDF]
, 2017 Urease is a nickel-dependent enzyme that catalyses the rapid hydrolysis of urea, determining an overall increase of pH and causing negative consequences for human health as well as agriculture.
Mazzei, Luca <1986>
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Enhancement efficacy of omeprazole by conjugation with silver nanoparticles as a urease inhibitor
Green Processing and SynthesisOmeprazole, a proton pump inhibitor, is used for gastric and duodenal ulcers, gastroesophageal reflux disease, Helicobacter pylori infection, etc. Current research is based on the loading of omeprazole on surface silver nanoparticles by chemical method ...
Zia Aneesa +10 more
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Negative Chemotaxis of Urease‐Functionalized Polymeric Microcapsules
Small, EarlyView.Urease‐functionalized PLGA microcapsules exhibit negative chemotaxis in urea gradients, migrating from high to low substrate concentrations. Increasing gradients enhance chemotaxis until a plateau, while increasing average substrate concentration in a fixed gradient reverses chemotactic behavior.
Amanda Hopkins +2 more
wiley +1 more source
Synthetic transformation of 6-Fluoroimidazo[1,2-a]Pyridine-3-carbaldehyde into 6-Fluoroimidazo[1,2-a]Pyridine-Oxazole Derivatives: In vitro urease inhibition and in silico study. [PDF]
Saudi Pharm J, 2023 Hussain R +7 more
europepmc +1 more source
A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance
Small, EarlyView.Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib +10 more
wiley +1 more source