Results 111 to 120 of about 116,102 (224)

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Effects of Chronic Kidney Disease and Uremic Toxins on Extracellular Vesicle Biology

, 2020
International audienceVascular calcification (VC) is a cardiovascular complication associated with a high mortality rate, especially in patients with diabetes, atherosclerosis or chronic kidney disease (CKD).
Ausseil, Jérôme, Boullier, Agnès, Linda Yaker, Yaker, Linda, Jérôme Ausseil, Kamel, Saïd, Agnès Boullier, Saïd Kamel   +7 more
core   +1 more source

Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation

Journal of Cutaneous Pathology, Volume 53, Issue 12, Page 1102-1106, December 2026.
ABSTRACT Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ...
Shrina Patel, Brad Graham, Kaci Reaves, Mya Phelps   +3 more
wiley   +1 more source

Impact of Heat Block Drying on Morphologic Preservation and Staining of Peripheral Blood Smears

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1341-1347, December 2026.
ABSTRACT Introduction Morphologic evaluation of the peripheral blood smear is critical for diagnosis and ruling out certain hematologic disorders. While air‐drying is standard, some laboratories may use heat blocks to expedite drying. Excessive heat may induce morphologic artifacts, but there is a lack of systematic literature on this practice ...
Ryan C. Shean, Nicolas Mavromatis, Gary Isom, Angie Turnbow, Lauren Pearson   +4 more
wiley   +1 more source

Uremic Toxins and Lipases in Haemodialysis : A Process of Repeated Metabolic Starvation

, 2014
Severe kidney disease results in retention of uremic toxins that inhibit key enzymes for lipid breakdown such as lipoprotein lipase (LPL) and hepatic lipase (HL).
Bernd Stegmayr, Stegmayr, Bernd,, Stegmayr, Bernd   +2 more
core   +1 more source

Hemorrhagic Papilledema in a Patient With End‐Stage Renal Disease and Meningioma: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Anterior cranial fossa meningioma can present with a constellation of symptoms that pose a diagnostic challenge, especially in patients with significant comorbidities like end‐stage renal disease (ESRD). We report a case where the classic triad of visual loss, headache, and anosmia was initially complicated by the patient's renal background ...
Farid Shekarchian, Mahdi Rafiee, Ghodsieh Zamani, Saeedeh‐sadat Mirtooni, Yoones Moniri   +4 more
wiley   +1 more source

Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis

Cardiovascular disease (CVD) frequently occurs in patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The mechanisms behind this may be related to traditional risk factors and CKD-specific factors that accelerate ...
Shiori Yoshida, Takuya Wakamatsu, Suguru Yamamoto, Ichiei Narita   +3 more
core   +1 more source

Severe Plasmodium vivax Malaria Presenting With Circulatory Shock and Coagulation Abnormalities: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Severe Plasmodium vivax malaria may cause vasopressor‐requiring shock, profound thrombocytopenia, jaundice, coagulation activation, and transient cardiopulmonary abnormalities. Early parasite confirmation and close monitoring for evolving organ dysfunction are essential.
Bushra Majid, Azmat Ullah Jan, Fatima Aman, Ahmad Ali, Waseem Abbas, Asim Shah, Ali Shir Erkin, Suleman Khan, Aizaz Anwar Khalid   +8 more
wiley   +1 more source

Right Ventricular Dysfunction and Ventriculo‐Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype‐Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies

Clinical Cardiology, Volume 49, Issue 11, November 2026.
Right ventricular dysfunction affects 19%–33% of patients With heart failure With preserved ejection fraction and is associated With exercise intolerance, hospitalization, and mortality. Assessing right ventricular function and its coupling with the pulmonary circulation may improve risk stratification and support management tailored to distinct ...
Amarelle Chamoun, Talha Farooq, Suhayya Batool, Sadia Tameez‐ud—din, Muhammad Yousaf, Preet Memon, Mohsin Ali, Arun Kumar Maloth, F. N. U. Sawaira, Muhammad Taimur Khan, Mohammad Eisa Ali, Mansoor Khalid, Maleeha Pandit, Kamil Ahmad Kamil   +13 more
wiley   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source