Results 101 to 110 of about 27,152 (233)
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, EarlyView.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications
Toxins, 2019 Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF.
Fumi Yamagami +3 more
doaj +1 more source
Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure [PDF]
, 2015 Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently removed through hemodialysis.
Chao, Pei-Dawn Lee +5 more
core +2 more sources
Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes
Hemodialysis International, EarlyView.ABSTRACT Pregnancy in women with end‐stage kidney disease (ESKD) requiring dialysis remains high risk, with significant maternal and fetal complications. While fertility rates are markedly reduced in this population, advances in dialysis care and obstetric management have led to increasing reports of successful pregnancies.
Shreepriya Mangalgi, Silvi Shah
wiley +1 more source
Toxins, 2018 Uremic toxins, such as indoxyl sulfate (IS) and p-cresol, or p-cresyl sulfate (PCS), are markedly accumulated in the organs of chronic kidney disease (CKD) patients.
Wen-Chih Liu +2 more
doaj +1 more source
Hepatology Research, EarlyView.Patients with hepatocellular carcinoma (HCC) as well as chronic kidney disease (CKD) are high‐risk individuals, making it challenging to accurately predict their survival. We found that the PALBI grade model when combined with other patient's clinical and tumor‐related factors, forms a new and highly accurate prediction tool to estimate their ...
Jihye Lim +2 more
wiley +1 more source
Toxins, 2019 Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascular risk. The clearance of these uremic toxins using current hemodialysis techniques is limited due to their hydrophobicity and ...
Marieke Sternkopf +12 more
doaj +1 more source
Two patients with history of STEC-HUS, posttransplant recurrence and complement gene mutations [PDF]
, 2013 Hemolytic uremic syndrome (HUS) is a disease of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. About 90% of cases are secondary to infections by Escherichia coli strains producing Shiga-like toxins (STEC-HUS), while 10% are ...
Alberti, M. +8 more
core +1 more source
Uremic toxins and peritoneal dialysis
Kidney International, 2001 Uremic toxicity is related in part to the accumulation of toxic substances, the nature of which has only partly been characterized. Because of the use of a highly permeable membrane and better preservation of the residual renal function, it could be anticipated that some of these uremic toxins are more efficiently cleared across the peritoneal membrane,
Lameire, Norbert +2 more
openaire +2 more sources
Associação entre indoxil sulfato e histomorfometria óssea em pacientes renais crônicos pré-diálise [PDF]
, 2014 Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy.
Barreto, Daniela Veit +9 more
core +4 more sources