Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway. [PDF]
PLoS ONE, 2013 Accumulating clinical evidence suggests that hyperuricemia is associated with an increased risk of type 2 diabetes. However, it is still unclear whether elevated levels of uric acid can cause direct injury of pancreatic β-cells.
Lu Jia +11 more
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The Role of the Intestine in the Development of Hyperuricemia
Frontiers in Immunology, 2022 Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui Yin +5 more
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Redox Report, 2022 Introduction Uric acid and edaravone might exert a neuroprotective effect in amyotrophic lateral sclerosis (ALS) by reducing oxidative stress. We analyzed whether the treatment effect of edaravone is pronounced in patients whose uric acid level increased
Hee Jo Han +4 more
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Correlation of Serum Uric Acid and Serum Uric Acid/Creatinine Ratio Levels with Adverse Pregnancy Outcomes in Late Pregnancy [PDF]
Zhongguo quanke yixueBackground The disorder of serum uric acid metabolism during pregnancy is associated with adverse pregnancy outcomes, while few studies have analyzed and compared the correlation of serum uric acid and serum uric acid/creatinine ratio levels with adverse
ZHAO Ru, HAN Chen, HUANG Zeyu, WANG Qian, HU Jun, GE Zhijuan, BI Yan, SHEN Shanmei
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Haseki Tıp Bülteni, 2020 Aim:It has been proposed that elevated levels of uric acid (UA) has a protective effect against the development of Idiopathic Parkinson’s Disease (IPD), however, since IPD has been found to be more common in gout patients, their relationship became ...
Vasfiye Burcu Albay, Mesude Tütüncü
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Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate
Scientific Reports, 2023 The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate.
Wojciech Żyłka +8 more
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Antiepileptic drugs reduce serum uric acid [PDF]
, 1987 Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls.
Arab +7 more
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Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]
, 2016 BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc +12 more
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Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
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In vitro analysis of urinary stone composition in dual-energy computed tomography [PDF]
, 2018 Purpose: Dual energy computed tomography (DECT) is a new method of computed tomography (CT) imaging, allowing the assessment of not only the object's morphology, but also its composition.
Chrzan, Robert +2 more
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