Results 101 to 110 of about 96,444 (318)

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

BMC Biology, 2019
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella, Lorela Ciraku, Mauricio J. Reginato   +2 more
doaj   +1 more source

Transcriptomic characterization of two major Fusarium resistance quantitative trait loci (QTLs), Fhb1 and Qfhs.ifa-5A, identifies novel candidate genes [PDF]

, 2013
Fusarium head blight, caused by Fusarium graminearum, is a devastating disease of wheat. We developed near-isogenic lines (NILs) differing in the two strongest known F.
Adam, G. (Gerhard), Ametz, Christian, Berthiller, Franz, Buerstmayr, Hermann, Jia, Haiyan, Kreil, David, Lemmens, Marc, Muehlbauer, Gary J., Schweiger, W. (Wolfgang), Siegwart, Gerald, Steiner, B. (Barbara), Wiesenberger, Gerlinde   +11 more
core   +1 more source

Evaluation of Characteristics and Ethnic Sensitivity for FDA‐Approved Drugs with Racial and Ethnic Differences in Pharmacokinetics, Safety, and Efficacy

The Journal of Clinical Pharmacology, EarlyView.
Abstract Racial and ethnic differences in drug disposition and response may have a significant impact on its risk‐benefit balance. Therefore, it is important to examine whether an investigational drug has characteristics that make the pharmacokinetics (PK), safety, and efficacy likely to be affected by intrinsic and extrinsic ethnic factors based on ...
Kei Fukuhara, Yusuke Tanetsugu, Shinsuke Wada, Chieko Muto, Norisuke Kawai   +4 more
wiley   +1 more source

Enzymatic Redox Cascade for One-Pot Synthesis of Uridine 5′-Diphosphate Xylose from Uridine 5′-Diphosphate Glucose

Advanced Synthesis and Catalysis, 2014
Synthetic ways towards uridine 5′-diphosphate (UDP)-xylose are scarce and not well established, although this compound plays an important role in the glycobiology of various organisms and cell types.
T. Eixelsberger, B. Nidetzky
semanticscholar   +1 more source

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII [PDF]

, 2008
Regulation of intracellular cyclic adenosine 3’, 5’-monophosphate (cAMP) by multiple pathways enables differential function of this ubiquitous second messenger in a context dependent manner.
Collins, Julie, Davis, Richard, Fraser, Iain D., Jiang, Lily I., Sternweis, Paul C.   +4 more
core   +2 more sources

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Bilirubin - Uridine Diphosphate Glucuronosyltransferase (Ugt1a1) Gene Mutations Among Newborn Babies In The Malay Population In Kelantan With Hyperbilirubinaemia [PDF]

, 2005
Sind rom Gilbert berpunca daripada keabnormalan pada gen uridine diphosphate-glucuronosyltransferase 1A 1 (UGT1A 1) yang disebabkan oleh mutasi. Mutasi-mutasi ini berbeza bagi setiap populasi dan kebanyakannya menjadi faktor asas bagi jaundis di ...
Yusoff, Surini
core   +3 more sources

An integrative strategy used by the aphid Uroleucon formosanum to counter host sesquiterpene lactone defense: Insights from combined genomic and transcriptomic analysis

Insect Science, EarlyView.
We report the first high‐quality chromosome‐level genome assembly for the aphid Uroleucon formosanum, a serious pest that infests lettuce in eastern Asia. A combination of comparative genomic analyses and RNA‐seq transcriptome profiling suggests that U. formosanum employs integrative mechanisms to cope with host plant‐derived sesquiterpene lactone (STL)
Jing‐Bo Li, Li‐Yun Jiang, Ge‐Xia Qiao, Jing Chen   +3 more
wiley   +1 more source

Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry.

Analytical Chemistry, 2012
Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism. Methods for absolute quantification of UGT1A1 and UGT1A6 were previously established utilizing stable isotope peptide ...
David E. Harbourt, J. K. Fallon, S. Ito, T. Baba, J. Ritter, G. Glish, Philip C. Smith   +6 more
semanticscholar   +1 more source