The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan+2 more
core
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. [PDF]
Acebrón-García-de-Eulate M+12 more
europepmc +1 more source
GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed
Hwang, Bum-Yeol+6 more
core
Uridine diphosphate glucose confers oxidative stress tolerance in microalgae. [PDF]
Zhang R+9 more
europepmc +1 more source
Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions. [PDF]
Park SC, Kim YJ, Kim JW.
europepmc +1 more source
Uridine diphosphate N-acetylglucosamine orchestrates the interaction of GlmR with either YvcJ or GlmS in Bacillus subtilis. [PDF]
Foulquier E+4 more
europepmc +1 more source
Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury. [PDF]
Jiang JL+10 more
europepmc +1 more source
A universal polyphosphate kinase: PPK2c of Ralstonia eutropha accepts purine and pyrimidine nucleotides including uridine diphosphate. [PDF]
Hildenbrand JC, Teleki A, Jendrossek D.
europepmc +1 more source
Insights from Structure-Based Simulations into the Persulfidation of Uridine Diphosphate-Glycosyltransferase71c5 Facilitating the Reversible Inactivation of Abscisic Acid. [PDF]
Li M+8 more
europepmc +1 more source
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are associated with insecticide resistance in the major malaria vectors Anopheles gambiae s.l. and Anopheles funestus. [PDF]
Logan RAE+3 more
europepmc +1 more source