Theoretical pKa prediction of the α-phosphate moiety of uridine 5′-diphosphate-GlcNAc
The pKa value of the α-phosphate moiety of uridine 5'-diphosphate-GlcNAc (UDP-GlcNAc) has been successfully calculated using density functional theory methods in conjunction with the Polarizable Continuum Models. Theoretical methods were benchmarked over
Bhavani Prasad Vipperla (20126115) +3 more
core
Uridine 5′-diphosphate N-acetylglucosamine (UDP-GlcNAc) is a natural UDP-monosaccharide donor for bacterial glycosyltransferases, while uridine 5′-diphosphate N-trifluoacetyl glucosamine (UDP-GlcNTFA) is its synthetic mimic.
Chen Qi (2803873) +5 more
core +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Uridine Diphosphate-glucose Dehydrogenase as a Prostate Cancer Biomarker Candidate
Prostate cancer is the most common cancer in men. Early detection and diagnosis could potentially lead to a higher cancer survival rate. In this study, the expression of the enzyme uridine diphosphate-glucose dehydrogenase was examined as a possible ...
Cavanagh, Brittin
core
The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang +8 more
wiley +1 more source
ANALYSIS OF BILIRUBIN WITH URIDINE-5'-DIPHOSPHATE GLUCURONYLTRANSFERASE.
Use of bilirubin uridine 5$\sp\prime$-diphosphate glucuronyltransferase, for the analysis of bilirubin was studied. Microsomal suspensions, as well as the solubilized enzyme, demonstrated capacities for a kinetic assay of albumin: bilirubin (1:2 ...
SHIVJI, ALLY.
core
Bilirubin-uridine diphosphate glucuronosyltransferase (UGT1A1) gene mutations among newborn babies in the Malay population in Kelantan with hyperbilirubinaemia [RJ276. S961 2005 f rb]. [PDF]
Sindrom Gilbert berpunca daripada keabnormalan pada gen uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) yang disebabkan oleh mutasi. Gilbert syndrome is caused by defects in the uridine diphosphateglucuronosyltransferase 1A1 (UGT1A1 ...
Yusoff, Surini, Yusoff, Surini
core
Metabolism of uridine 5′-diphosphate-glucose in golgi vesicles from pea stems
Uridine 5′-diphosphate-glucose (UDP-Glc) is transported into the lumen of the Golgi cisternae, where is used for polysaccharide biosynthesis. When Golgi vesicles were incubated with UDP-[3H]Glc, [3H]Glc was rapidly transferred to endogenous acceptors and
Orellana, Ariel, Neckelmann, Guy
core +1 more source
Structure−Activity Relationships of Uridine 5‘-Diphosphate Analogues at the Human P2Y6 Receptor
The structure−activity relationships and molecular modeling of the uracil nucleotide activated P2Y6 receptor have been studied. Uridine 5‘-diphosphate (UDP) analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate group ...
Pedro Besada (2487034) +9 more
core +2 more sources
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche +5 more
wiley +1 more source

