Results 101 to 110 of about 22,157 (221)

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

BMC Biology, 2019
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella, Lorela Ciraku, Mauricio J. Reginato   +2 more
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Characterization and tissue specificity of a monoclonal antibody against human uridine 5'-diphosphate-glucuronosyltransferase

, 1987
A monoclonal antibody against human liver uridine 5'-diphosphate-glucuronosyltransferase (UDPGTase) was developed. Enzyme inhibition studies with this monoclonal antibody showed inhibition of human liver UDPGTase activity with bilirubin, 4 ...
Allebes, W. A., Peters, W. H., Jansen, P. L., Capel, P. J., Poels, L. G.   +4 more
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Ganglioside biosynthesis. Characterization of uridine diphosphate galactose: GM2 galactosyltransferase in Golgiapparatus from rat liver

Journal of Lipid Research, 1976
An enzyme that transfers galactose from UDP-Gal to ganglioside GM2 (Tay-Sachs ganglioside) was concentrated 50 times in Golgi apparatus from rat liver relative to total homogenates.
F E Wilkinson, D J Morré, T W Keenan
doaj   +1 more source

Analysis of drug metabolic disorder using recombinant uridine diphosphate-glucuronosyltransferase.

, 2002
Others学位授与機関：　滋賀医科大学　博士（医学）第388号　平成14年3月25日1) Effect of a conserved mutation in uridine diphosphate glucuronosyltransferase 1A1 and 1A6 on glucuronidation of a metabolite of flutamide. European Journal of Clinical Pharmacology.
伊藤, 誠紀
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Human placental glucuronidation and transport of 3 ' azido-3 '-deoxythymidine and uridine diphosphate glucuronic acid

, 2003
These studies were performed to characterize the contribution of the uridine diphosphate glucuronosyltransferase (UGT) enzymes to the clearance of 3′-azido-3′-deoxythymidine (AZT) in vivo and to assess the regulation of UGT activity [including the ...
Abby C. Collier, Jeffrey A. Keelan, Keelan, Jeffrey A., Mitchell, Murray D., Murray D. Mitchell, Pierre E. Van Zijl, van Zijl, Pierre E., Tingle, Malcolm D., James W. Paxton, Collier, Abby C., Paxton, James W., Malcolm D. Tingle   +11 more
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Chemoenzymatic Synthesis of 4‑Fluoro‑N‑Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis

, 2017
Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were prepared using both chemical and chemoenzymatic syntheses relying on N-acetylglucosamine-
Paul L. DeAngelis (2117743), Victor L. Schultz (3718729), Kathryn Linkens (3718732), Robert J. Linhardt (710659), Xing Zhang (11943), Jenna Rimel (3718726), Dixy E. Green (2117737)   +6 more
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Purification of uridine diphosphate glucuronyltransferase

, 1983
Detoxification of compounds occurs in two phases. In phase I, a functional group on the toxicant is made available for subsequent Phase II reactions. In phase II, the functional groups are conjugated to a compound that will increase the solubility of the
Duffaud, Guy Daniel
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A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei. [PDF]

, 2013
Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many organisms including Trypanosoma brucei, the etiological agent of Human African Trypanosomiasis.
Harrison, Justin, Eskilsson, Susanne, van Aalten, Daan M. F., Collie, Iain T., Hopkins Navratilova, Iva, Ferguson, Michael A. J.; id_orcid, Navratilova, Iva Hopkins, Urbaniak, Michael D., Frearson, Julie A., Ferguson, Michael A J, Raimi, Olawale G., Aristotelous, Tonia, Urbaniak, Mick, Raimi, Olwale G., Fang, Wenxia   +14 more
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Uridine and uridine nucleotides as novel regulators of nucb2/nesfatin-1 neuron activation: An immunohistochemical study

Nesfatin-1, identified as an anorexigenic neuropeptide in the hypothalamus, is activated by glutamatergic agonists and innervated by excitatory and inhibitory neurons.
Salman, B., Topal, G., Hasanoglu Akbulut, N., Cansev, M., Koc, C., Coskan, N., Eyigor, O.   +6 more
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Perioperative Anaesthetic Management of a Patient of Gilbert’s Syndrome with Adult Congenital Heart Disease - A Rare Presentation

The Indian Anaesthetists' Forum, 2014
Gilbert's syndrome is a hereditary condition with the genetic mutation of the enzyme uridine diphosphate glucuronosyltransferase, characterized by intermittent jaundice in the absence of hemolysis or underlying liver disease.
Sambhunath Das, Neelam Agarwal
doaj