Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections
Small Science, EarlyView.This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton +3 more
wiley +1 more source
Transcriptomic characterization of two major Fusarium resistance quantitative trait loci (QTLs), Fhb1 and Qfhs.ifa-5A, identifies novel candidate genes [PDF]
, 2013 Fusarium head blight, caused by Fusarium graminearum, is a devastating disease of wheat. We developed near-isogenic lines (NILs) differing in the two strongest known F.
Adam, G. (Gerhard) +11 more
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Insect Science, EarlyView.We report the first high‐quality chromosome‐level genome assembly for the aphid Uroleucon formosanum, a serious pest that infests lettuce in eastern Asia. A combination of comparative genomic analyses and RNA‐seq transcriptome profiling suggests that U. formosanum employs integrative mechanisms to cope with host plant‐derived sesquiterpene lactone (STL)
Jing‐Bo Li +3 more
wiley +1 more source
Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII [PDF]
, 2008 Regulation of intracellular cyclic adenosine 3’, 5’-monophosphate (cAMP) by multiple pathways enables differential function of this ubiquitous second messenger in a context dependent manner.
Collins, Julie +4 more
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De novo pyrimidine nucleotide biosynthesis in isolated rat glomeruli [PDF]
, 1986 De novo pyrimidine nucleotide biosynthesis in isolated rat glomeruli. Uracil ribonucleotide–sugars and aminosugars are required for glomerular basement membrane (GBM) biosynthesis.
Cortes, Pedro +2 more
core +1 more source
Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells [PDF]
, 2015 We report the successful expression and purification of functional human muscle glycogen synthase (GYS1) in complex with human glycogenin-1 (GN1). Stoichiometric GYS1:GN1 complex was produced by co-expression of GYS1 and GN1 using a bicistronic pFastBac™-
Hunter, Roger W. +4 more
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Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. [PDF]
, 2018 O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism.
Chen, Xi +11 more
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Hematologically important mutations: bilirubin UDP-glucuronosyltransferase gene mutations in Gilbert and Crigler-Najjar syndromes. [PDF]
, 2005 Gilbert and Crigler-Najjar syndromes are familial unconjugated hyperbilirubinemias caused by genetic lesions involving a single complex locus encoding for bilirubin UDP-glucuronosyltransferase (UGT1A1) gene.
Costa, Elísio
core +1 more source
P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]
, 1998 The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Barnard, EA +3 more
core
British Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain +6 more
wiley +1 more source