Results 111 to 120 of about 7,719 (211)
The FASEB Journal, 2018 The focus of this project was to explore the structure of the GlmU protein from E. coli (PDB ID: 2OI7) and to design and build a physical model that illustrates the key functional features of the protein.
M. Roarke Tollar +3 more
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Journal of Biological Chemistry, 1990 We have isolated a portion of the uridine diphosphate N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-glucosamine-1-phosphate transferase gene (GTR2) from the genome of a tunicamycin-resistant clonal Chinese hamster ovary cell line, 3E11. The genomic fragment was selected by its hybridization to the yeast ALG-7 gene at low stringency.
J R, Scocca, S S, Krag
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, 2005 GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed
Hwang, Bum-Yeol +6 more
core
Aberrant O-GlcNAcylated proteins: New perspectives in breast and colorectal cancer
Frontiers in Endocrinology, 2014 Increasing glucose consumption is thought to provide an evolutionary advantage to cancer cells. Alteration of glucose metabolism in cancer influences various important metabolic pathways including the hexosamine biosynthesis pathway (HBP), a relatively ...
Parunya eChaiyawat +5 more
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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
PLoS Genetics, 2020 The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N ...
Emma B Alme +4 more
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Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities [PDF]
, 2019 Mammalian protein N-glycosylation requires the transfer of an oligosaccharide containing 2 residues of N-acetylglucosamine, 9 residues of mannose and 3 residues of glucose (Glc3Man9 GlcNAc2) from Glc3Man9GlcNAc2-diphospho (PP)-dolichol (DLO) onto ...
Bosco, Michael +10 more
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The Journal of Clinical Investigation, 2023 Major depressive disorder is a common and devastating psychiatric disease, and the prevalence and burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in the pathophysiology ...
Jun Fan +16 more
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Clinical, biochemical and molecular characterization of Korean patients with mucolipidosis II/III and successful prenatal diagnosis [PDF]
, 2017 Background: Mucolipidosis types II and III (ML II/III) are autosomal recessive disorders caused by a deficiency in the lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.
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Food BioengineeringMicrobial fermentation is a potent strategy for eco‐friendly and sustainable chitin oligosaccharide (CHOS) production. Nonetheless, hurdles (e.g., imbalanced metabolic flow and the need for uridine diphosphate (UDP)‐sugar donor consumption in CHOS ...
Chen Deng +5 more
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Recent advances in small molecule LpxC inhibitors against gram-negative bacteria (2014–2024)
Frontiers in MicrobiologyIn 2024, WHO added multiple multidrug-resistant (MDR) Gram-negative bacteria to the bacteria priority pathogens list, and the continued increase in MDR Gram-negative bacteria poses a serious threat to public health.
Pengpeng Ji +3 more
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