Results 51 to 60 of about 7,626 (203)

Metabolic Control of Cardiomyocyte Cell Cycle

Methodist DeBakey Cardiovascular Journal, 2023
Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes.
Ivan Menendez-Montes, Daniel J. Garry, Jianyi (Jay) Zhang, Hesham A. Sadek   +3 more
doaj   +1 more source

Relationship between glycolysis and exopolysaccharide biosynhesis in Lactococcus lactis [PDF]

, 2001
The relationships between glucose metabolism and exopolysaccharide (EPS) production in a Lactococcus lactis strain containing the EPS gene cluster (Eps ) and in nonproducer strain MG5267 (Eps) were characterized.
Ramos, A., Boels, I.C., Vos, W.M., de, Santos, H.   +3 more
core   +1 more source

Structures ofBacteroides fragilisuridine 5′-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA) [PDF]

Acta Crystallographica Section D Biological Crystallography, 2015
Uridine 5′-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes a reversible reaction for adding anO-acyl group to the GlcNAc in UDP-GlcNAc in the first step of lipid A biosynthesis. Lipid A constitutes a major component of lipopolysaccharides, also referred to as endotoxins, which form the outer monolayer of the outer membrane
Ngo, Alice, Fong, Kai T, Cox, Daniel L, Chen, Xi, Fisher, Andrew J   +4 more
openaire   +3 more sources

UPLC-QE-MS Analysis of the Differences in Milk Metabolites from Guanzhong Dairy Goats at the Peak and Late Lactation Stages [PDF]

Shipin Kexue
In order to explore the dynamic changes of metabolites in goat milk during different lactation periods, the differential metabolites in milk from Guanzhong dairy goats at the peak and late lactation stages were investigated by ultra-high performance ...
YU Mengqi, YUAN Yuxin, CHEN Lu, SHARI Akang, REN Xinyang, QU Yingxin, LI Guang
doaj   +1 more source

Antitoxin ε Reverses Toxin ζ-Facilitated Ampicillin Dormants

Toxins, 2020
Toxin-antitoxin (TA) modules are ubiquitous in bacteria, but their biological importance in stress adaptation remains a matter of debate. The inactive ζ-ε2-ζ TA complex is composed of one labile ε2 antitoxin dimer flanked by two stable ζ toxin monomers ...
María Moreno-del Álamo, Chiara Marchisone, Juan C. Alonso   +2 more
doaj   +1 more source

Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]

, 2016
Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina, Pertusati, Fabrizio, Serpi, Michaela   +2 more
core   +1 more source

Effects of exercise on the hexosamine biosynthetic pathway and glycosylation

Journal of Physical Fitness and Sports Medicine, 2012
Minor amounts of glucose incorporated into the cells is metabolized via the hexosamine biosynthetic pathway, resulting in the production of uridine-5’-diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is utilized as a donor substrate for the N- and O ...
Ken Shirato, Takako Kizaki, Hideki Ohno, Kazuhiko Imaizumi   +3 more
doaj   +1 more source

AglH, a thermophilic UDP‑N‑acetylglucosamine‑1‑phosphate:dolichyl phosphate GlcNAc‑1‑phosphotransferase initiating protein N‑glycosylation pathway in Sulfolobus acidocaldarius, is capable of complementing the eukaryal Alg7 [PDF]

, 2016
AglH, a predicted UDP-GlcNAc-1-phosphate:dolichyl phosphate GlcNAc-1-phosphotransferase, is initiating the protein N-glycosylation pathway in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. AglH successfully replaced the endogenous GlcNAc-1-
A Bouhss, A Larkin, A Larkin, A Spang, A Typas, AJ Lloyd, AO Amer, AO Amer, AR Nogare Dal, B Chaban, B Chaban, Benjamin H. Meyer, BH Meyer, BH Meyer, BH Meyer, C Ginsberg, C Whitfield, C Yanisch-Perron, D Calo, D Calo, D Mumberg, DC Alexander, DJ Mancuso, DW Grogan, E Hartmann, FA Troy, G Paul, G Samuel, G Schmidt, H Shams-Eldin, Hosam Shams-Eldin, J Jaeken, J Lehrer, J Lu, JD Esko, JM Archibald, K Hjort, KF Jarrell, KJ Glover, KJ Stone, KR Mclachlan, L Guy, L Kaminski, L Masson, L Xu, M Wagner, M Wagner, MA Lehrman, MG Elferink, MM Chang, MS Anderson, N Kurosawa, O Wurtzel, P Burda, PA Amor, R Mazhari-Tabrizi, RS Sikorski, S Brown, S Ohnuma, S Ohnuma, S Yamashita, S Yurist-Doutsch, Sonja-Verena Albers, TD Brock, TD Bugg, U Meier-Dieter, U Zahringer, V Eckert, W Meyer, Y Boucher, Y Taguchi, Z Guan, Z Guan, ZQ Guan   +73 more
core   +2 more sources

Inhibition of glycolysis-driven immunosuppression with a nano-assembly enhances response to immune checkpoint blockade therapy in triple negative breast cancer

Nature Communications, 2023
Immune-checkpoint inhibitors (ICI) are promising modalities for treating triple negative breast cancer (TNBC). However, hyperglycolysis, a hallmark of TNBC cells, may drive tumor-intrinsic PD-L1 glycosylation and boost regulatory T cell function to ...
Xijiao Ren, Zhuo Cheng, Jinming He, Xuemei Yao, Yingqi Liu, Kaiyong Cai, Menghuan Li, Yan Hu, Zhong Luo   +8 more
doaj   +1 more source

Synthese des 18F-markierten Coenzyms Uridindiphosphatglucose als Basis für die 18F-Glykosylierung von Glykoproteinen [PDF]

, 2000
The chemo-enzymatic radiosynthesis of no carrier added (n.c.a.) uridine diphospho-2-deoxy- 2-[$^{18}$F]fluoro-$\alpha$-D-glucose (UDP-[$^{18}$F]FGlc) was developed.
Prante, Olaf
core