Results 71 to 80 of about 7,719 (211)

Sugar nucleotide quantification by liquid chromatography tandem mass spectrometry reveals a distinct profile in Plasmodium falciparum sexual stage parasites [PDF]

, 2017
The obligate intracellular lifestyle of Plasmodium falciparum and the difficulties to obtain sufficient amounts of biological material has hampered the study of specific metabolic pathways in the malaria
Dinglasan, Rhoel R., Izquierdo Lázaro, Luis, López Gutiérrez, Borja   +2 more
core   +2 more sources

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

AglH, a thermophilic UDP‑N‑acetylglucosamine‑1‑phosphate:dolichyl phosphate GlcNAc‑1‑phosphotransferase initiating protein N‑glycosylation pathway in Sulfolobus acidocaldarius, is capable of complementing the eukaryal Alg7 [PDF]

, 2016
AglH, a predicted UDP-GlcNAc-1-phosphate:dolichyl phosphate GlcNAc-1-phosphotransferase, is initiating the protein N-glycosylation pathway in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. AglH successfully replaced the endogenous GlcNAc-1-
A Bouhss, A Larkin, A Larkin, A Spang, A Typas, AJ Lloyd, AO Amer, AO Amer, AR Nogare Dal, B Chaban, B Chaban, Benjamin H. Meyer, BH Meyer, BH Meyer, BH Meyer, C Ginsberg, C Whitfield, C Yanisch-Perron, D Calo, D Calo, D Mumberg, DC Alexander, DJ Mancuso, DW Grogan, E Hartmann, FA Troy, G Paul, G Samuel, G Schmidt, H Shams-Eldin, Hosam Shams-Eldin, J Jaeken, J Lehrer, J Lu, JD Esko, JM Archibald, K Hjort, KF Jarrell, KJ Glover, KJ Stone, KR Mclachlan, L Guy, L Kaminski, L Masson, L Xu, M Wagner, M Wagner, MA Lehrman, MG Elferink, MM Chang, MS Anderson, N Kurosawa, O Wurtzel, P Burda, PA Amor, R Mazhari-Tabrizi, RS Sikorski, S Brown, S Ohnuma, S Ohnuma, S Yamashita, S Yurist-Doutsch, Sonja-Verena Albers, TD Brock, TD Bugg, U Meier-Dieter, U Zahringer, V Eckert, W Meyer, Y Boucher, Y Taguchi, Z Guan, Z Guan, ZQ Guan   +73 more
core   +2 more sources

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Pedro Merino, Veronica Juste, Alejandro Montesa, Sandra Pereira, Sara Orta, Manuel Pedrón, Ana I. Jiménez, Sonsoles Martín‐Santamaría, Ramón Hurtado‐Guerrero, Ignacio Delso, Tomás Tejero   +10 more
wiley   +1 more source

Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in [PDF]

, 2009
Background Nikkomycins are a group of peptidyl nucleoside antibiotics and act as potent inhibitors of chitin synthases in fungi and insects. Nikkomycin X and Z are the main components produced by Streptomyces ansochromogenes.
Yang Haihua, Li Lei, Li Jine, Liao Guojian, Tian Yuqing, Tan Huarong   +5 more
core   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

In Silico Screening and Analysis of Broad-Spectrum Molecular Targets and Lead Compounds for Diarrhea Therapy

Bioinformatics and Biology Insights, 2019
Diarrhoeal disease kills about 1.5 million human beings per year across the continents. The enterotoxigenic Escherichia coli (ETEC) pathotype has been noted as a major cause of diarrheal disease in human and livestock.
Harriet U Ugboko, Obinna C Nwinyi, Solomon U Oranusi, Toluwase H Fatoki, Paul A Akinduti, Jesupemi M Enibukun   +5 more
doaj   +1 more source

Systematic analyses of glutamine and glutamate metabolisms across different cancer types

Chinese Journal of Cancer, 2017
Background Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such ...
Yuan Tian, Wei Du, Sha Cao, Yue Wu, Ning Dong, Yan Wang, Ying Xu   +6 more
doaj   +1 more source

Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice

Nature Communications, 2023
The hexosamine biosynthetic pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to facilitate O-linked GlcNAc (O-GlcNAc) protein modifications, and subsequently enhance cell survival under lethal stresses.
Xin Zhang, Can Hu, Zhen-Guo Ma, Min Hu, Xiao-Pin Yuan, Yu-Pei Yuan, Sha-Sha Wang, Chun-Yan Kong, Teng Teng, Qi-Zhu Tang   +9 more
doaj   +1 more source