Results 81 to 90 of about 7,719 (211)

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]

, 2018
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik, Bogachev V. S., Daan M. F. van Aalten, Derossi D., Dong D. L., Karim Rafie, Riccardo Trapannone, Torres C. R., Vladimir S. Borodkin   +8 more
core   +3 more sources

Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. [PDF]

, 2018
O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism.
Chen, Xi, Chen, Yi, Guo, Jianshuang, Li, Jing, Li, Shanshan, Li, Yanhong, Wang, Jiajia, Wang, Peng George, Wen, Liuqing, Zang, Lanlan, Zhang, Jiabin, Zhu, Hailiang   +11 more
core  

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Bacterial Cellulose Synthase Catalyzes the Formation of Chitin

ChemistrySelect, Volume 11, Issue 15, 20 April 2026.
Recombinant BcsA‐B from Rhodobacter sphaeroides is shown to cleave UDP‐GlcNAc (uridine diphosphate N‐acetylglucosamine), generating chitin with distinct β‐chitin Raman bands. These findings reveal that a cellulose synthase can process an alternative nucleotide sugar, providing biochemical evidence for the co‐synthesis of cellulose and chitin.
Neraz Shai, Sapir Korman Shadmi, Mariela J. Pavan, Filipe Natalio   +3 more
wiley   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma

Scientific Reports
Glaucoma is the leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form globally and has been linked to mitochondrial dysfunction and energy deficiency.
Yizhen Tang, Xuanqi Zhang, Xiaoxiao Chen, Jiayong Li, Minyue Xie, Qianru Wu, Yinghan Zhang, Chi-wai Do, Xinghuai Sun   +8 more
doaj   +1 more source

Toxin ζ Triggers a Survival Response to Cope with Stress and Persistence

Frontiers in Microbiology, 2017
Bacteria have evolved complex regulatory controls in response to various environmental stresses. Protein toxins of the ζ superfamily, found in prominent human pathogens, are broadly distributed in nature.
María Moreno-del Álamo, Mariangela Tabone, Virginia S. Lioy, Juan C. Alonso   +3 more
doaj   +1 more source

Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions [PDF]

, 2016
published_or_final_versio
Cai, Z, Fu, L, Guan, X, Kanawati, B, Lin, SH, Liu, T, MING, X, Schmitt-Kopplin, P, Tang, Z   +8 more
core   +1 more source

Efficient chemoenzymatic synthesis of uridine 5′-diphosphate N-acetylglucosamine and uridine 5′-diphosphate N-trifluoacetyl glucosamine with three recombinant enzymes

Preparative Biochemistry & Biotechnology, 2017
Uridine 5′-diphosphate N-acetylglucosamine (UDP-GlcNAc) is a natural UDP-monosaccharide donor for bacterial glycosyltransferases, while Uridine 5′-diphosphate N-trifluoacetyl glucosamine (UDP-GlcNTFA) is its synthetic mimic. The chemoenzymatic synthesis of UDP-GlcNAc and UDP-GlcNTFA was attempted by three recombinant enzymes.
Xiaoyan, Li, Chen, Qi, Peilian, Wei, Lei, Huang, Jin, Cai, Zhinan, Xu   +5 more
openaire   +2 more sources

Feedback Inhibition of l -Glutamine d -Fructose 6-Phosphate Amidotransferase by Uridine Diphosphate N -Acetylglucosamine in Neurospora crassa [PDF]

Journal of Bacteriology, 1970
The enzyme, l -glutamine d -fructose 6-phosphate amidotransferase (EC 2.6.1.16) of Neurospora crassa , which catalyzes the formation of glucosamine 6-phosphate was shown to be subject to feedback inhibition by uridine diphosphate N -acetyl-
A, Endo, K, Kakiki, T, Misato
openaire   +2 more sources