Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases
Frontiers in Endocrinology, 2018 The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway are considered as nutrient sensors that regulate several essential biological processes.
Ninon Very +4 more
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Disruption of the MreB Elongasome Is Overcome by Mutations in the Tricarboxylic Acid Cycle
Frontiers in Microbiology, 2021 The bacterial actin homolog, MreB, is highly conserved among rod-shaped bacteria and essential for growth under normal growth conditions. MreB directs the localization of cell wall synthesis and loss of MreB results in round cells and death.
Brody Barton +2 more
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Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis [PDF]
, 2006 Metabolic engineering has recently been embraced as an effective tool for developing whole-cell biocatalysts for oligosaccharide and polysaccharide synthesis.
Anne Ruffing, Rachel Chen
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Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption [PDF]
Biochemical Journal, 1977 Glucuronidation of oestrone and of oestradiol in microsomal fractions was markedly and significantly stimulated by UDP-N-acetylglucosamine and by ultrasonication: Triton X-100 also stimulated. This is consistent with compartmentation of UDP-glucuronyl-transferase. Stimulation by UDP-N-acetylglucosamine may be physiologically significant.
J, Wilkinson, T, Hallinan
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Frontiers in Microbiology, 2023 Bacterial biofilm is an emerging form of life that involves cell populations living embedded in a self-produced matrix of extracellular polymeric substances (EPS).
Ting Zhang +15 more
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Characterization of Yeast Yea4p, a Uridine Diphosphate-N-acetylglucosamine Transporter Localized in the Endoplasmic Reticulum and Required for Chitin Synthesis [PDF]
Journal of Biological Chemistry, 2000 Chitin is an essential cell wall component, synthesis of which is regulated throughout the cell cycle in the yeast Saccharomyces cerevisiae. We cloned an S. cerevisiae gene, YEA4, whose product is homologous to the Kluyveromyces lactis uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter.
S K, Roy +3 more
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Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]
, 2008 Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Paradis-Bleau , Catherine +6 more
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Frontiers in Pharmacology, 2019 Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies.
Mei-Ling Han +12 more
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Regulatory mechanism of O-linked N-acetylglucosamine protein modification on autophagy in cancer. [PDF]
Clin Transl MedO‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Li Y +5 more
europepmc +2 more sources
PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis.
PLoS Pathogens, 2019 Bacterial pathogens have evolved strategies that enable them to invade tissues and spread within the host. Enterococcus faecalis is a leading cause of local and disseminated multidrug-resistant hospital infections, but the molecular mechanisms used by ...
Yusibeska Ramos +10 more
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