A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]
, 2016 Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I +2 more
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Uridine diphosphate N-acetylglucosamine stimulates uptake of nutrients by quiescent BALB/C3T3 cells. [PDF]
Proceedings of the National Academy of Sciences, 1978 Preincubation of quiescent BALB/C3T3 cells with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) in conditioned medium resulted in a time- and concentration-dependent stimulation of uptake of 2-deoxyglucose, uridine, and alpha-aminoisobutyric acid over that seen in conditioned medium alone.
Natraj, C V, Datta, P
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Uridine diphosphate-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinasedeletion in mice leads to lethal intracerebral hemorrhage during embryonic development [PDF]
Glycobiology, 2021 AbstractAmong the enzymes of the biosynthesis of sialoglycoconjugates, uridine diphosphate-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), catalyzing the first essential step of the sialic acid (Sia) de novo biosynthesis, and cytidine monophosphate (CMP)-Sia synthase (CMAS), activating Sia to CMP-Sia, are particularly important.
Henri, Wedekind +10 more
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Preparation of Uridine Diphosphate- N -Acetylgalactosamine from Uridine Diphosphate- N -Acetylglucosamine by Using Microbial Enzymes [PDF]
Applied and Environmental Microbiology, 1981 A method was developed for the large scale preparation of uridine diphosphate- N -acetylgalactosamine (UDP-GalNAc) from uridine diphosphate- N -acetylglucosamine (UDP-GlcNAc) by means of microbial enzymes.
K, Yamamoto, H, Kawai, T, Tochikura
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Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
BMC Biology, 2019 Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella +2 more
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Identification of a carbohydrate recognition motif of purinergic receptors
eLife, 2023 As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao +7 more
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The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans. [PDF]
, 2017 Background: The pathogenic potential of Candida albicans depends on adhesion to the host cells mediated by highly glycosylated adhesins, hyphae formation and growth of biofilm. These factors require effective N-glycosylation of proteins.
Janik, Anna +5 more
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Scientific Reports, 2017 In Bacillus subtilis, Listeria monocytogenes and in two Mycobacteria, it was previously shown that yvcK is a gene required for normal cell shape, for optimal carbon source utilization and for virulence of pathogenic bacteria.
Elodie Foulquier, Anne Galinier
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Molecules, 2020 The synthesis of hitherto unknown 5′-deoxy-5′-(4-substituted-1,2,3-triazol-1-yl)-uridine and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved in Mycobacterium tuberculosis (Mtb), are described.
Vincent Hervin +6 more
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Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetylglucosamine transporter from Kluyveromyces lactis. [PDF]
Proceedings of the National Academy of Sciences, 1996 The mannan chains of Kluyveromyces lactis mannoproteins are similar to those of Saccharomyces cerevisiae except that they lack mannose phosphate and have terminal alpha1-->2-linked N-acetylglucosamine. The biosynthesis of these chains probably occurs in the lumen of the Golgi apparatus, by analogy to S. cerevisiae.
Abeijon, Claudia +2 more
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