Results 81 to 90 of about 7,626 (203)

Expression and molecular characterization of an intriguing hyaluronan synthase (HAS) from the symbiont “Candidatus Mycoplasma liparidae” in snailfish [PDF]

PeerJ
Background Hyaluronan synthases (HASs) are ubiquitous in living organisms, and the hyaluronic acid (HA) synthesized by them are important to their body and well used in medicine, cosmetics and other fields.
Lulu Guo, Shaolu Wang, Chunang Lian, Lisheng He   +3 more
doaj   +2 more sources

Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs [PDF]

, 2019
O-Linked α-N-acetylgalactosamine (O-GalNAc) glycans constitute a major part of the human glycome. They are difficult to study because of the complex interplay of 20 distinct glycosyltransferase isoenzymes that initiate this form of glycosylation, the ...
Bertozzi, Carolyn R., Choi, Junwon, Debets, Marjoke F., Gehring, Jase, Gray, Melissa A., Malaker, Stacy A., Schumann, Benjamin, Takashima, Megumi, Timmermans, Suzanne B. P. E., Wagner, Lauren J. S.   +9 more
core   +3 more sources

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments

iScience, 2018
Summary: We apply stable isotope tracing, mass-spectrometry-based untargeted metabolomics, to reveal the biochemical space labeled by 13C-substrates in bone-marrow-derived macrophages. At the pathway level, classically (lipopolysaccharide [LPS]-polarized,
Patrycja Puchalska, Xiaojing Huang, Shannon E. Martin, Xianlin Han, Gary J. Patti, Peter A. Crawford   +5 more
doaj   +1 more source

Stochastic dynamics mass spectrometric structural analysis of nucleotides [PDF]

The paper deals with innovative equations tackling exactly stochastic dynamics mass spectrometric experimental variable intensity of peak per span of scan time.
Ivanova, Bojidarka
core   +2 more sources

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening [PDF]

, 2019
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Eadsforth, Thomas C., Fedorov, Roman, Führing, Jana, Gray, David, Post, John, Prakash, Ohm, Routier, Françoise H., Shepherd, Sharon M.   +7 more
core   +3 more sources

Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review

Cell Death Discovery
Glutamine: fructose-6-phosphate amidotransferase (GFAT), a conserved enzyme across prokaryotic and eukaryotic species, is the first and rate-limiting step in the hexosamine biosynthetic pathway (HBP), diverting 2–5% of fructose-6-phosphate derived from ...
Caiting Yang, Fengyu Chu, Xiaoli Chen, Fanqi Meng, Yinhao Li, Jingwen Chen, Chaoyang Sun, Yahui Shang, Ruibin Guo, Jianming Wang, Changxin Wu, Huiping Duan, Miaomiao Shao, Wei Yuan   +13 more
doaj   +1 more source

Nationwide patient registry for GNE myopathy in Japan [PDF]

, 2014
BACKGROUND: GNE myopathy is a slowly progressive autosomal recessive myopathy caused by mutations in the GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) gene.
En Kimura, Harumasa Nakamura, Ichizo Nishino, Madoka Mori-Yoshimura, Miho Murata, Naohiro Yonemoto, Shin’ichi Takeda, Yukiko K Hayashi   +7 more
core   +1 more source

N-acetylglucosamine supplementation fails to bypass the critical acetylation of glucosamine-6-phosphate required for Toxoplasma gondii replication and invasion.

PLoS Pathogens
The cell surface of Toxoplasma gondii is rich in glycoconjugates which hold diverse and vital functions in the lytic cycle of this obligate intracellular parasite.
María Pía Alberione, Víctor González-Ruiz, Olivier von Rohr, Serge Rudaz, Dominique Soldati-Favre, Luis Izquierdo, Joachim Kloehn   +6 more
doaj   +1 more source

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Determining Factors Influencing Nuclear Envelope and Nuclear Pore Complex Structure. [PDF]

, 2013
The cell’s nuclear envelope (NE) has pores that are stabilized by nuclear pore complexes (NPC), large proteinaceous structures whose function is to mediate transport between the nucleus and cytoplasm.
Gouni, Sushanth
core   +1 more source